BAFF antibody

Catalog No. ABIN317073

The Mouse Monoclonal anti-BAFF antibody (Clone 2B) (ABIN317073) specifically detects BAFF in EIA. The antibody is reactive with Human samples.

Quick Overview for BAFF antibody (ABIN317073)

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BAFF antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Clone: 2B

Product Details anti-BAFF Antibody

Specificity: This antibody specifically recognises CD257 (otherwise known as BAFF/BLyS). This antibody has not been cross-adsorbed and may react with homologous proteins from related species.

Characteristics: Synonyms: TNFSF13B, BLYS, TALL1, TNFSF20, ZTNF4, Tumor necrosis factor ligand superfamily member13B, TNF- and APOL-related leukocyte expressed ligand 1, B lymphocyte stimulator, Bcell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule

Purification: Purified IgG prepared by affinity chromatography on Protein A

Immunogen: Recombinant full-length mature human CD257 expressed in E. coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 5 - 6g/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Reconstitute with 0.5 mL distilled water

Concentration: 1.0mg/mL

Buffer: Phosphate buffered saline pH 7.2

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. Caution:

Expiry Date: 12 months

Target Details for BAFF

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Alternative Name: CD257 / BAFF

Background: CD257 is a 285 amino acid type II transmembrane protein and member of the tumor necrosis factor (TNF) superfamily of ligands, which acts as a B and T cell stimulator and plays a role in the development of autoimmune diseases such as systemic lupus erythematosus. CD257 is expressed by monocytes, macrophages, T cells and dendritic cells and acts through binding to CD267 (TACI), CD269 (BCMA) and CD268 (BAFFR) receptors, the latter interaction playing a critical role in the activation, survival, differentiation and proliferation of B cells.Synonyms: B cell-activating factor, B lymphocyte stimulator, BAFF, BLYS, Dendritic cell-derived TNF-like molecule, TALL1, TNF- and APOL-related leukocyte expressed ligand 1, TNFSF13B, TNFSF20, Tumor necrosis factor ligand superfamily member 13B, ZTNF4

Gene ID: 10673

UniProt: Q9Y275

Pathways: NF-kappaB Signaling, Production of Molecular Mediator of Immune Response