Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 2 (EMR2) antibody

Antigen: Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 2 (EMR2)

Synonyms: CD312, DKFZp781B135, EMR2

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN317649

Additional Information

Characteristics: Synonyms: EGF-like module-containing mucin-like hormone receptor-like 2, EGF-like module EMR2

Alternative name: CD312 / EMR2

Swiss-Prot: Q9UHX3

Cross-Reactivity: Human

Description: EMR2 is a member of the class B seven-span transmembrane (TM7) receptor familyexpressed predominantly by cells of the immune system, where it has been shown to berestricted specifically to monocytes and granulocytes. Family members are characterizedby an extended extracellular region with a variable number of N terminal epidermal growthfactor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. Thisgene is closely linked to the gene encoding egf-like molecule containing mucin-likehormone receptor 3 on chromosome 19. This protein does not interact with the liganddecay accelerating factor for complement, unlike the related CD97 antigen, and indicatesthat these very closely related proteins likely have nonredundant functions. This generesults in multiple transcripts encoding distinct isoforms. ESTs have been isolated fromblood, colon, lymph node, placenta, spleen, testis, and uterus libraries.

Specificity: This antibody detects endogenous levels of EMR2 protein. Species: Human. Others not tested.

Application Details

Application Notes: ELISA: 1/1000-1/5000. Western Blot: 1/500-1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 1.0 mg/ml

Purification: Aff - Purified

Buffer: Phosphate buffered saline (PBS), pH~7.2 containing 15 mM Sodium Azideas preservative.

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: One year from despatch.

Restrictions: For Research Use only