PAQR7 antibody

Catalog No. ABIN317756

The Rabbit Polyclonal anti-PAQR7 antibody is suitable to detect PAQR7 in samples from Human. It has been validated for WB and IF.

Quick Overview for PAQR7 antibody (ABIN317756)

Target: PAQR7 (Progestin and AdipoQ Receptor Family Member VII (PAQR7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAQR7 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-PAQR7 Antibody

Specificity: MPRα antibody detects endogenous levels of mPRα protein.

Purification: Affinity chormatography

Application Details

Application Notes: ELISA: 1: 1000approx. 1: 5000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PAQR7

Target: PAQR7 (Progestin and AdipoQ Receptor Family Member VII (PAQR7))

Background: The steroid progesterone induces the resumption of maturation in oocytes via a nongenomic pathway through binding to a novel, membrane progestin receptor (mPR). This pathway inhibits adenylyl cyclase and reduces intracellular cAMP, and also activates mitogen-activated protein kinase to effect signal transduction pathways. Three distinct groups, designated α, β and γ, comprise this gene family. mPRα, also designated progestin and adipoQ receptor family member VII (PAQR7), consists of an extracellular N-terminus, an intracellular C-terminus, and seven transmembrane domains. It is expressed in ovary, testis, placenta, uterus and bladder. mPRβ, also designated progestin and adipoQ receptor family member VIII (PAQR8), consists of eight putative transmembrane regions and an intracellular N-terminus that contains a leucine-rich motif. It is a 354 amino acid protein with a molecular mass of about 40 kDa and is expressed in brain and spinal cord. Both mPRα and mPRβ may be G protein-coupled receptors and may be involved in oocyte maturation.Synonyms: Membrane progestin receptor alpha, Progestin and adipoQ receptor family member 7, Progestin and adipoQ receptor family member VII, mPR alpha

Molecular Weight: approx. 40 kDa

Gene ID: 164091

NCBI Accession: NP_848509

UniProt: Q86WK9