IL4 Receptor antibody

Catalog No. ABIN317795

The Rabbit Polyclonal anti-IL4 Receptor antibody is suitable to detect IL4 Receptor in samples from Human and Mouse. It has been validated for WB and IF.

Quick Overview for IL4 Receptor antibody (ABIN317795)

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL4 Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-IL4 Receptor Antibody

Specificity: This antibody detects endogenous levels of IL-4R-alpha protein.(region surrounding Gly493)

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1: 1000approx. 1: 4000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 15 mM Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IL4 Receptor

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Alternative Name: CD124 / IL4R

Background: IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine and mucus production at sites of allergic inflammmation. The IL4 response is involved in promoting Th2 differentiation. The secreted extracellular domain of IL4R alpha, called sIL4R alpha, can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. It has no signaling abilities. Allelic variations in the IL4RA gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema.Synonyms: 582J2.1, IL-4R-alpha, IL4 Receptor alpha, IL4RA, Interleukin-4 receptor alpha chain

Molecular Weight: approx. 88.0 kDa

Gene ID: 3566

NCBI Accession: NP_000409

UniProt: P24394

Pathways: JAK-STAT Signaling, Positive Regulation of Immune Effector Process