CRABP2 antibody

Catalog No. ABIN317901

The Rabbit Polyclonal anti-CRABP2 antibody (ABIN317901) specifically detects CRABP2 in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for CRABP2 antibody (ABIN317901)

Target: CRABP2 (Cellular Retinoic Acid Binding Protein 2 (CRABP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRABP2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CRABP2 Antibody

Specificity: This antibody detects endogenous levels of CRABP-II protein.(region surrounding Pro81)

Purification: Affinity Chromatography using epitope-specific immunogen

Application Details

Application Notes: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 with 0.05 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CRABP2

Target: CRABP2 (Cellular Retinoic Acid Binding Protein 2 (CRABP2))

Alternative Name: CRABP2

Background: The cellular retinoic acid-binding protein (CRABP)-I and a related isoform CRABP-II are nuclear receptors for retinoic acid (RA), an important regulator of cell growth and differentiation in fetal and adult tissues. These CRABP proteins mediate the downstream effects of RA in distinct ways. CRABP-I negatively regulates the activity of RA by enhancing the production of RAmetabolizing enzymes and increasing the rate at which RA is degraded. CRABP-II enhances the effects of RA by directly interacting with RA receptors (RAR) and, in turn, promoting the formation of RAR-RA complexes and stimulating RA-mediated gene transcription. Both CRABP-I and CRABP-II are expressed in the embryo, and CRABP-I is ubiquitously expressed in various adult tissues. The expression of CRABP-II is elevated in cells that synthesize relatively large amounts of RA, and it is also predominantly expressed in skin, uterus, ovary, and in the choroid plexus.Synonyms: CRABP-II, Cellular retinoic acid-binding protein 2, Cellular retinoic acid-binding protein II

Molecular Weight: approx. 16 kDa

Gene ID: 1382

NCBI Accession: NP_001186652

UniProt: P29373