CLCC1 antibody

Catalog No. ABIN317902

This Rabbit Polyclonal antibody specifically detects CLCC1 in WB and IF. It exhibits reactivity toward Human.

Quick Overview for CLCC1 antibody (ABIN317902)

Target: CLCC1 (Chloride Channel CLIC-Like 1 (CLCC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLCC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-CLCC1 Antibody

Specificity: This antibody detects endogenous levels of CLCC1 protein.(region surrounding Asp429)

Purification: Affinity Chromatography using epitope-specific immunogen

Application Details

Application Notes: ELISA: 1/40000approx. 1/60000. Western Blot: 1/500approx. 1/1000. Immunofluorescence: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CLCC1

Target: CLCC1 (Chloride Channel CLIC-Like 1 (CLCC1))

Alternative Name: CLCC1

Background: Chloride channels (CLCs) regulate cellular traffic of chloride ions, a critical component of all living cells. CLCs are involved in membrane potential stabilization, signal transduction, cell volume regulation and organic solute transport. CLCC1 (Chloride channel CLIC-like protein 1), also known as MCLC (Mid-1-related chloride channel) or KIAA0761, is a 551 amino acid multi-pass membrane protein that belongs to the chloride channel MCLC family. CLCC1 is related to the Saccharomyces cerevisiaeprotein Mid-1 and is believed to function as an intracellular chloride channel that is expressed in lung, brain, muscle, liver and testis. Localizing to intracellular compartments such as the Golgi apparatus, the endoplasmic reticulum (ER) and the nuclear envelope, CLCC1 is expressed as four isoforms due to alternative splicing events, namely hMCLC-1, hMCLC-2, hMCLC-3 and hMCLC-4.Synonyms: Chloride channel CLIC-like protein 1, KIAA0761, MCLC, Mid-1-related chloride channel protein 1

Molecular Weight: approx. 62 kDa

Gene ID: 23155

NCBI Accession: NP_001041675

UniProt: Q96S66

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection