FNTB antibody

Catalog No. ABIN317932

This Rabbit Polyclonal antibody specifically detects FNTB in WB. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for FNTB antibody (ABIN317932)

Target: FNTB (Farnesyltransferase subunit beta (FNTB))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FNTB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FNTB Antibody

Specificity: FTβ antibody detects endogenous levels of FTβ protein.(region surrounding Glu285)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FNTB

Target: FNTB (Farnesyltransferase subunit beta (FNTB))

Alternative Name: FNTB

Background: Mammalian protein farnesyl transferases are heterodimeric proteins containing two nonidentical α and β subunits that attach farnesyl residues to a cysteine at the fourth position from the COOH terminus of several proteins, including nuclear lamins and p21Ras proteins. The natural substrates contain the Cys-A-A-Xaa recognition sequence, where the A residues are aliphatic and Xaa represents methionine, serine, glutamine or cysteine. The purified farnesyl transferase is an α-β heterodimer. The β subunit binds the peptide substrate while the α subunit is suspected to participate in formation of a stable complex with the substrate farnesyl pyrophosphate. The α subunit is shared with a second prenyl transferase, geranyl-geranyl transferase, that attaches 20 carbon geranylgeranyl to Ras related proteins that terminate in a Cys-A-A-Xaa recognition site in which Xaa is leucine.Synonyms: CAAX farnesyltransferase subunit beta, FTase-beta, Protein farnesyltransferase subunit beta, Ras proteins prenyltransferase subunit beta

Molecular Weight: approx. 50 kDa

Gene ID: 2342

NCBI Accession: NP_002019

UniProt: P49356