Chemokine (C-C Motif) Receptor 8 (CCR8) antibody

Antigen: Chemokine (C-C Motif) Receptor 8 (CCR8)

Synonyms: CY6, TER1, CKRL1, CDw198, CKR-L1, CMKBR8, CMKBRL2, GPR-CY6, MGC129966, MGC129973

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN319016

Additional Information

Characteristics: Synonyms: C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, GPR-CY6, Chemokinereceptor-like 1, TER1, CMKBRL2, CC-chemokine receptor CHEMR1, CKRL1, CMKBR8

Alternative name: CDw198 / CCR8

Swiss-Prot: P51685

Immunogen: Peptide corresponding to amino acids 183 to 201 of human CDw198 (CCR8).

Cross-Reactivity: Human

Isotype: IgG  (Matching secondary antibodies)

Description: CCR8 is a member of the beta chemokine receptor family, which is predicted to be a seventransmembrane protein similar to G protein coupled receptors. Chemokines and theirreceptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activationregulated cytokine (TARC) and macrophage inflammatory protein 1 beta (MIP1 beta) havebeen identified as ligands of this receptor. Studies of this receptor and its ligandssuggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. Morespecifically, this receptor may contribute to the proper positioning of activated T cellswithin the antigenic challenge sites and specialized areas of lymphoid tissues. This gene islocated at the chemokine receptor gene cluster region. CCR8 expression has been reportedin spleen and thymus, natural killer cells, monocytes, and T cells, and at lower levels inperipheral blood leukocytes. CCR8 is also believed to be alternative coreceptor with CD4for HIV-1 infection.

Specificity: This antibody recognises the chemokine receptor CCR8, also known as CDw198, which hasbeen identified as a co-receptor for HIV infection. CCR8 is a receptor for the humanchemokine 1-309 which is expressed on spleen, thymus and T lymphoblastic cell lines. This antibody detects a band of approximately 50kD. Species: Human. Others not tested.

Application Details

Application Notes: Western Blot: 1: 500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.5 mg/ml

Purification: Purified

Buffer: Phosphate buffered saline containing 0.02% Sodium Azide

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Research Area: Chemokines, Receptors

Restrictions: For Research Use only