Islet Amyloid Polypeptide (IAPP) antibody

Antigen: Islet Amyloid Polypeptide (IAPP)

Synonyms: DAP, IAP, AMYLIN, IAPP, Iapp, LOC100230121, Amylin

Clonality: Polyclonal

Host: Chicken

Reactivity: Human

Application: Western Blotting (WB), ELISA

Catalog no.: ABIN334637

Additional Information

Immunogen: synthetic peptide based on human IAPP sequence:K-C-N-T-A-T-C-A-T-Q-R-L-A-N-F-L-V-H-S-S-N-N-F-G-A-I-L-S-S-T-N-V-G-S-N-T-Y

Format: Liquid

Description: Amylin, or Islet Amyloid Polypeptide (IAPP) P10997, is a 37-residue peptidehormone secreted by pancreatic beta-cells at the same time as insulin (in a roughly1:100 amylin:insulin ratio). Islet, or insulinoma, almyloid polypeptide (IAPP, oramylin) is commonly found in pancreatic islets of patients suffering diabetesmellitus type 2, or harboring an insulinoma. While the association of amylin with thedevelopment of type 2 diabetes has been known for some time, a direct causativerole for amylin has been harder to establish. Recent results suggest that amylin,like the related beta-amyloid (Abeta) associated with Alzherimer's disease, caninduce apoptotic cell-death in particular cultured cells, an effect that may berelevant to the deleopment of type 2 diabetes.

Specificity: Predicted reactivity: cat, dog, mouse, rat.

Application Details

Application Notes: Recommended Dilution 1:1000 (WB), 1:1000 (ELISA).

Buffer: Total IgY in PBS pH 8.0 + 0.02% sodium azide

Storage: store at 4°C, make aliquots to avoid working with a stock. Please, remember tospin tubes briefly prior to opening them to avoid any losses that might occur fromliquid material adhering to the cap or sides of the tubes.

Restrictions: For Research Use only

Images

anti-Islet Amyloid Polypeptide (IAPP) antibody