KLKB1 antibody

Catalog No. ABIN342152

The Mouse Monoclonal anti-KLKB1 antibody is suitable to detect KLKB1 in samples from Human. It has been validated for ELISA and WB.

Quick Overview for KLKB1 antibody (ABIN342152)

Target: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KLKB1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Clone: 13G11

Product Details anti-KLKB1 Antibody

Specificity: Specifically recognizes in human plasma two variants (88 kD and 85 kD) of prekallikrein and its activation products kallikrein (88 kD and 85 kD), the complexes formed by kallikrein with its endogenous inhibitors C1 inhibitor, alpha-2-macroglobulin and antithrombin III, and 45 kD prekallikrein/kallikrein fragment(s). It also recognizes prekallikrein and its activation products in chimpanzee, rhesus, and baboon plasmas. The epitope for this antibody, located on the prekallikrein/kallikrein heavy chain, is involved in the interaction between prekallikrein and factor XIIa. This antibody inhibits prekallikrein activation in human and rhesus plasmas by approximately 60-80 % and 55 %, respectively. Does not cross-react with tissue kallikrein.

Purification: Protein G purified

Immunogen: Human plasma prekallikrein.

Type of Immunogen: Purified protein

Isotype: IgG1

Application Details

Application Notes: Approved: ELISA, WB

Usage: May be used in ELISA and Western blots to identify/quantitate prekallikrein and its activation products in plasmas of humans, chimpanzees, rhesus monkeys, and baboons. NOTE: Prekallikrein activation may occur with repeated freezing/thawing (3x or more) of plasma samples obtained from humans or other primates.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles.

Target Details for KLKB1

Target: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Alternative Name: KLKB1 / Plasma Kallikrein

Background: Name/Gene ID: KLKB1
Subfamily: Serine S1
Family: Protease

Synonyms: KLKB1, Fletcher factor deficiency, Fletcher factor, Kininogenin, Plasma kallikrein, PKK deficiency, Plasma kallikrein heavy chain, PPK, Prekallikrein deficiency, Plasma kallikrein light chain, Plasma prekallikrein, Kallikrein 3

Gene ID: 3818

UniProt: P03952

Pathways: Complement System, Brown Fat Cell Differentiation