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Epidermal Growth Factor Receptor (EGFR) (pTyr1173) antibody

Antigen

Epidermal Growth Factor Receptor (EGFR)
Synonyms
ERBB, HER1, mENA, ERBB1, PIG61, Wa5, wa2, Erbb, Errp, wa-2, AI552599, 9030024J15Rik, ErbB-1, C-erb, D-EGFR, D-Egf, DEGFR, DER, DER flb, DER/EGFR, DER/faint little ball, DER/top, DER/torpedo, DmHD-33,  ... show more
Epitope
Alternatives

pTyr1173
Clonality Monoclonal (EM-13)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Application
Alternatives Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
Catalog no. ABIN343717
Quantity 0.1 mg  (1 mg/ml)
Price 429.00 $   Plus shipping costs $35.00
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anti-Epidermal Growth Factor Receptor (EGFR) (pTyr1173) antibody

Additional Information
Application Details Images Alternatives Secondary Antibodies back to top

Alternative name EGFR (Phospho-Tyr1173)
Immunogen Synthetic phospho-peptide covering sequence around tyrosine 1173 of human EGFR.
Format Purified
Isotype IgG1  (Matching secondary antibodies)
Clone EM-13
Description The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, isa member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDatransmembrane glycoprotein is often associated with cancerogenesis, although its activationstate is controlled at various levels including trafficking and degradation steps. Binding ofreceptor-specific ligands to the EGFR ectodomain results in formation of homodimeric orheterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferredpartner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways leadto cell proliferation and survival responses.
Specificity The antibody EM-13 reacts with human EGFR (ErbB1 / HER1) phosphorylated on tyrosine1173.
Synonyms ERBB, HER1, mENA, ERBB1, PIG61, Wa5, wa2, Erbb, Errp, wa-2, AI552599, 9030024J15Rik, ErbB-1, C-erb, D-EGFR, D-Egf, DEGFR, DER, DER flb, DER/EGFR, DER/faint little ball, DER/top, DER/torpedo, DmHD-33, EFG-R, EGF-R, EGFR, EK2-6, Egf, El, Elp, Elp-1, Elp-B1, Elp-B1RB1, HD-33, Torpedo/DER, Torpedo/Egfr, c-erbB, d-egf-r, dEGFR1, flb, l(2)05351, l(2)09261, l(2)57DEFa, l(2)57EFa, l(2)57Ea, pnt, top, top/DER, top/flb, DmelCG10079, CG10079, egfr, EGFR12, EGFR15, egfr1, Erbb2

Application Details
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Application Notes Western Blotting - Recommended dilution: 1 µg/ml. Positive control: EGF-stimulated A431. Negative control: Non-stimulated A431
Concentration 1 mg/ml
Purity > 95% (by SDS-PAGE)
Purification Purified from hybridoma culture supernatant by protein-A affinity chromatography.
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Storage Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.
Restrictions For Research Use only

Alternatives
Application Details Images Secondary Antibodies back to top

Alternatives for antigen "Epidermal Growth Factor Receptor (EGFR)", type "Antibodies"
Hosts Rabbit (418), Mouse (166), Rat (8), Sheep (7), Goat (2)
Reactivities Human (580), Mouse (Murine) (251), Rat (Rattus) (227), Dog (Canine) (33), Rabbit (18), Pig (Porcine) (17), Cow (Bovine) (6), Chicken (5), Horse (Equine) (2), Sheep (Ovine) (2)
Applications Western Blotting (WB) (417), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (134), Immunoprecipitation (IP) (119), Enzyme Immunoassay (EIA) (113), Immunohistochemistry (IHC) (103), Immunofluorescence (IF) (98), ELISA (92), Flow Cytometry (FACS) (89), Immunohistochemistry (Frozen Sections) (IHC (fro)) (43), Dot Blot (Dot) (28), Blocking Antibody (Inhibition) (16), Immunocytochemistry (ICC) (10), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (4), Functional Studies (Func) (3), ELISA (Detection) (2), Immunoelectron Microscopy (IEM) (2), Neutralization (Neut) (2), Blocking Antibody (Inhibition) (1)
Conjugates Biotin (35), FITC (5), Alexa Fluor 488 (3), PE (3), Alexa Flour 488 (2), Alexa Fluor 350 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), Gold (2), HRP (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), PE,Cy7 (2), RBITC (2)
Epitopes pTyr1197 (19), C-Term (16), pTyr869 (15), pTyr1092 (14), pTyr1172 (13), pThr678 (12), pTyr1110 (12), pSer1070 (11), pThr693 (10), N-Term (5), pTyr1016 (4), pTyr1069 (4), AA 1-203 (2), AA 1140-1160 (2), AA 960-980 (2), Extracell. non Ligand binding Site (2), S695 (2), Y1125 (2), Y869 (2), Y998 (2), pSer1026 (2), pSer1071 (2), pSer1166 (2), pSer1190 (2), pSer695 (2), pSer768 (2), pTyr1125 (2), pTyr998 (2), AA 1189-1199 (1), AA 985-996 (1), Ab-1016 (1), Ab-1026 (1), Ab-1069 (1), Ab-1071 (1), Amino Acids 1165-1186 (1), External Domain (1), Extracellular non-ligand binding site (1), S1026 (1), S1070 (1), S1071 (1), S1166 (1), S1190 (1), S991 (1), T678 (1), TYR1173 (1), Y1016 (1), Y1069 (1), Y1092 (1), Y1110 (1), Y1172 (1), Y978 (1), extracellular ligand binding site (1), internal (1), pS1070 (1), pS768 (1), pSer1142 (1), pSer967 (1), pTyr1101 (1), pTyr1173 (1), pTyr1173, pTyr1248 (1), pTyr992 (1), pY1016 (1), pY1092 (1), pY1172 (1), prylated At Threonine 654 (1), prylated At Tyrosine 1045 (1), prylated At Tyrosine 1173 (1), prylated At Tyrosine 845 (1), prylated at Serine 1047 (1)