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Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) (Cytoplasmic Domain) antibody

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Synonyms kcnj1, MGC68935, KIR1.1, ROMK, ROMK1, Kcnj, Kir1.1, Romk2, kir1.1, romk1, wu:fl37c05, zgc:63534
Cytoplasmic Domain
(17), (16), (15), (15), (2), (2), (2), (1), (1), (1), (1)
(78), (29), (28), (2), (1), (1), (1), (1), (1), (1), (1)
(64), (15), (1)
(7), (7), (7), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(52), (45), (11), (8), (6), (3), (1)
Pubmed 6 references available
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Quantity 500 μg
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the cytoplasmic domain of human KCNJ1 (ROMK1, Kir1.1) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is shares 92% identity with rat and mouse sequences.
Isotype IgG
Specificity Specific for KCNJ1.
Alternative Name KCNJ1 (KCNJ1 Antibody Abstract)
Background Function: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
Tissue specificity: In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver.
Subcellular location: Membrane, Multi-pass membrane protein. Involvement in disease: Defects in KCNJ1 are the cause of Bartter syndrome type 2 (BS2) also termed hyperprostanglandin E syndrome 2. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS2 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS2 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia. Also known as: ATP-sensitive inward rectifier potassium channel 1, Potassium channel, inwardly rectifying subfamily J member 1, ATP-regulated potassium channel ROM-K, Kir1.1, ROMK1.
Research Area Signaling, Metabolism
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers. ..." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Bock, Shuck, Benjamin et al.: "Nucleotide sequence analysis of the human KCNJ1 potassium channel locus." in: Gene, Vol. 188, Issue 1, pp. 9-16, 1997 (PubMed).

Simon, Karet, Rodriguez-Soriano et al.: "Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMK." in: Nature genetics, Vol. 14, Issue 2, pp. 152-6, 1996 (PubMed).

Yano, Philipson, Kugler et al.: "Alternative splicing of human inwardly rectifying K+ channel ROMK1 mRNA." in: Molecular pharmacology, Vol. 45, Issue 5, pp. 854-60, 1994 (PubMed).

Shuck, Bock, Benjamin et al.: "Cloning and characterization of multiple forms of the human kidney ROM-K potassium channel." in: The Journal of biological chemistry, Vol. 269, Issue 39, pp. 24261-70, 1994 (PubMed).

Krishnan, Desai, Ward et al.: "Isolation and chromosomal localization of a human ATP-regulated potassium channel." in: Human genetics, Vol. 96, Issue 2, pp. 155-60, 1995 (PubMed).

Catalog No. ABIN350383
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