NGFR antibody
Quick Overview for NGFR antibody (ABIN350707)
Target
See all NGFR AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Purpose
- Mouse monoclonal antibody to rat p75NTR (MC192)
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Specificity
- Specific for rat p75NTR.
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Cross-Reactivity
- Rat
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Purification
- Affinity purified
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Immunogen
- Nerve growth factor receptor (TNFR superfamily member 16)
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Application Notes
- WB IHC ELISA. A working concentration of 5-15 μg,ml is recommended. This antibody is suitable for use in paraformaldehyde fixed alcohol fixed,paraffin-embedded sections. The optimal working solution should be determined by the end user.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
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Handling Advice
- Avoid freeze and thaw cycles.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
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Expiry Date
- 12 months
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- NGFR (Nerve Growth Factor Receptor (NGFR))
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Alternative Name
- p75NTR
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Background
- FUNCTION: Low affinity receptor which can bind to NGF BDNF NT-3 and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer, disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2 TRAF4 TRAF6 PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein.
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Pathways
- NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
Target
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