Toll-Like Receptor 1 (TLR1) (C-Term) antibody

Details for Product No. ABIN357041
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Antigen
Synonyms CD281, TIL, TIL. LPRS5, rsc786
Epitope
C-Term
(23), (9), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(118), (58), (23), (17), (17)
Host
Rabbit
(92), (33), (6), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(10), (8), (7), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(84), (58), (40), (29), (24), (21), (14), (10), (8), (2), (2), (1)
Pubmed 2 references available
Quantity 0.4 mL
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Catalog No. ABIN357041
357.50 $
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of Mouse TLR1.
Specificity This antibody detects TLR1 at C-term.
Purification Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name CD281 / TLR1
Background Higher animals establish host defense by orchestrating innate and adaptive immunity. This is mediated by professional antigen presenting cells, i.e. dendritic cells (DCs). DCs can incorporate pathogens, produce a variety of cytokines, maturate, and present pathogen- derived peptides to T cells, thereby inducing T cell activation and differentiation. These responses are triggered by microbial recognition through type I transmembrane proteins, Toll-like receptors (TLRs) on DCs. TLRs consist of ten members and each TLR is involved in recognizing a variety of microorganism-derived molecular structures. TLR ligands include cell wall components, proteins, nucleic acids, and synthetic chemical compounds, all of which can activate DCs as immune adjuvants. Each TLR can activate DCs in a similar, but distinct manner. For example, TLRs can be divided into subgroups according to their type I interferon (IFN) inducing ability. TLR2 cannot induce IFN-alpha or IFN-beta, but TLR4 can lead to IFN-beta production. Meanwhile, TLR3, TLR7, and TLR9 can induce both IFN-alpha and IFN-beta. Recent evidences suggest that cytoplamic adapters for TLRs are especially crucial for this functional heterogeneity.
Alternate names: KIAA0012, TIL, Toll-like receptor 1, Toll/interleukin-1 receptor-like protein
Gene ID 21897, 10090
UniProt Q9EPQ1
Research Area Signaling, Immunology, Inflammation
Application Notes ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Toll-Like Receptor 1 (TLR1) (C-Term) antibody anti-Toll-Like Receptor 1 (TLR1) (C-Term) antibody
anti-Toll-Like Receptor 1 (TLR1) (C-Term) antibody (2) anti-Toll-Like Receptor 1 (TLR1) (C-Term) antibody (Image 2)
Background publications Ozinsky, Underhill, Fontenot et al.: "The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 25, pp. 13766-71, 2000 (PubMed).

Hajjar, OMahony, Ozinsky et al.: "Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 15-9, 2001 (PubMed).

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