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SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (N-Term)

Details for Product anti-SOX2 Antibody No. ABIN357437, Supplier: Login to see
Antigen
  • Qscn6
  • Qsox
  • Sox-2
  • rSOx
  • ANOP3
  • MCOPS3
  • RGD1565646
  • SRY-box2
  • Xsox-2
  • anop3
  • mcops3
  • sox-2
  • lcc
  • ysb
  • cb236
  • wu:fb83g04
  • wu:fc14d07
  • zgc:65860
  • zgc:77389
Epitope
N-Term
42
23
21
15
14
13
10
8
7
6
5
5
5
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Zebrafish (Danio rerio)
320
87
44
13
9
7
7
5
5
4
4
2
2
1
1
1
Host
Rabbit
256
65
7
4
Clonality
Polyclonal
Conjugate
This SOX2 antibody is un-conjugated
17
13
12
11
11
11
3
2
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
217
146
64
59
55
44
42
36
14
7
5
4
4
4
2
2
2
2
2
2
1
Supplier
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Immunogen This SOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97~126 amino selected from the N-terminal region of human SOX2.
Isotype Ig
Specificity This antibody detects SOX2 at N-term.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Zebrafish.
Species reactivity (tested):Human.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name SOX2 (SOX2 Antibody Abstract)
Background The intronless gene for SOX2 encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation.Synonyms: ANOP3, MCOPS3, SRY (sex determining region Y)-box 2, SRY-box 2, SRY-related HMG-box gene 2, Transcription factor SOX-2
Molecular Weight 34310 Da (based on amino acid sequence). Theoretical pI: 9.74.
Gene ID 6657, 9606
UniProt P48431
Research Area Embryogenesis, Embryonic stem cells, Reproduction, Transcription Factors, Neural Stem Cell marker
Pathways
Application Notes ELISA: 1/1,000. Western blot: 1/50-1/100. Immunohistochemistry: 1/10-1/50. Immunofluorescence: 1/10-1/50. Flow Cytometry: 1/10-1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (N-Term) (ABIN357437) anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (N-Term) antibody
 image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (N-Term) (ABIN357437) anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (N-Term) antibody (Image 2)
 image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (N-Term) (ABIN357437) anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (N-Term) antibody (Image 3)
 image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (N-Term) (ABIN357437) anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (N-Term) antibody (Image 4)
 image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (N-Term) (ABIN357437) anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (N-Term) antibody (Image 5)
Background publications Reményi, Lins, Nissen et al.: "Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers." in: Genes & development, Vol. 17, Issue 16, pp. 2048-59, 2003 (PubMed).

Wiebe, Nowling, Rizzino: "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 17901-11, 2003 (PubMed).

Fantes, Ragge, Lynch et al.: "Mutations in SOX2 cause anophthalmia." in: Nature genetics, Vol. 33, Issue 4, pp. 461-3, 2003 (PubMed).

Schepers, Teasdale, Koopman: "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families." in: Developmental cell, Vol. 3, Issue 2, pp. 167-70, 2002 (PubMed).

Kamachi, Uchikawa, Kondoh: "Pairing SOX off: with partners in the regulation of embryonic development." in: Trends in genetics : TIG, Vol. 16, Issue 4, pp. 182-7, 2000 (PubMed).