2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) (C-Term) antibody

Antigen: 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1)

Synonyms: OIAS, IFI-4, OIASI, OAS1, OAS1Z, DKFZp459F079

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Enzyme Immunoassay (EIA), Western Blotting (WB)

Catalog no.: ABIN358716

Additional Information

Characteristics: Synonyms: 2'-5'-oligoadenylate synthetase 1, p46/p42 OAS, (2-5')oligo(A) synthetase 1, 2-5Asynthetase 1

Alternative name: OAS1 / OIAS

Gene ID: 4938

Swiss-Prot: P00973

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated syntheticpeptide selected selected from the C-terminal region of human OAS1.

Cross-Reactivity: Human, Mouse (Murine)

Isotype: Ig  (Matching secondary antibodies)

Description: OAS1 is an interferon inducible protein that may play a role in mediating resistance to virusinfection, control of cell growth, differentiation, and apoptosis. It binds double-strandedRNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase Lthat, when activated, cleaves single-stranded RNAs. This protein is associated withdifferent subcellular fractions such as mitochondrial, nuclear, and rough/smoothmicrosomal fractions.

Specificity: This antibody reacts to OAS1. Species: Human, Mouse. Others not tested.

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/10 - 1/50. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: PBS with 0.09% (W/V) sodium azide

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. Caution: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Restrictions: For Research Use only