Decorin antibody

Catalog No. ABIN360879

The Rat Monoclonal anti-Decorin antibody (Clone 9A38) (ABIN360879) specifically detects Decorin in WB. The antibody is reactive with Mouse samples.

Quick Overview for Decorin antibody (ABIN360879)

Target: Decorin (DCN)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Decorin antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 9A38

Product Details anti-Decorin Antibody

Specificity: This antibody detects Mouse Decorin in Western blotting.

Purification: Protein A/G affinity chromatography

Immunogen: Recombinant Decorin

Isotype: IgG2

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 0.2 mL sterile PBS and the final concentration is 0.5 mg/mL.

Buffer: 0.2 μm filtered PBS solution

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Decorin

Target: Decorin (DCN)

Alternative Name: Decorin

Background: Secreted chondroitin/dermatan sulfate proteoglycan belonging to the class I small leucine-rich proteoglycan family (SLRP). All SLRP family members are characterized by the Nterminal and C terminal cysteine rich regions, which flank the central region containing 1012 tandem leucinerich repeats. In mouse Decorin, the glycosaminoglycan chain is Olinked to Ser34 in the Nterminal disulfide bridged loop. Decorin binds to fibronectin, TGFβ, type I and type II collagen. The binding of Decorin to these molecules is mediated via the core protein. Decorin plays a role in maintaining collagen fibrillogenesis. Depending on the cell context, Decorin can either block or augment the bioactivity of TGFβ Decorin induces growth suppression by activation of a signaling pathway that culminates in the blockade of the cell cycle machinery. Decorin can also induce fibroblast cytoskeletal and signalling changes that results in an increased cell migration (1 2).Synonyms: Bone proteoglycan II, DCN, PG-S2, PG40, SLRR1B

Gene ID: 13179

NCBI Accession: NP_001177380

UniProt: P28654

Pathways: Glycosaminoglycan Metabolic Process