IGFBP6 antibody

Catalog No. ABIN360903

The Rat Monoclonal anti-IGFBP6 antibody (Clone 21D24) (ABIN360903) specifically detects IGFBP6 in WB. The antibody is reactive with Mouse samples.

Quick Overview for IGFBP6 antibody (ABIN360903)

Target: IGFBP6 (Insulin-Like Growth Factor Binding Protein 6 (IGFBP6))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IGFBP6 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 21D24

Product Details anti-IGFBP6 Antibody

Purification: Protein A/G affinity chromatography

Immunogen: Recombinant protein of IGF-BP6

Isotype: IgG2

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IGFBP6

Target: IGFBP6 (Insulin-Like Growth Factor Binding Protein 6 (IGFBP6))

Alternative Name: IGFBP6

Background: IGFBP6 (IGF binding protein 6) is a member of the IGFBP family that regulates the actions of IGFs. It acts extracellularly in an autocrine/paracrine manner. IGFBP6 binds preferentially to IGF-II. IGFBP6 has been shown to inhibit the growth of tumour cells and to promote apotosis. IGFBP6 has been shown to be imported into the nuclei of rhabdomyosarcoma and HEK-293 cells. This is mediated by a NLS sequence that bears limited homology to those found in IGFBP-3 and -5. Deletion of the NLS segment abolishes the pro-apoptotic effect of IGFBP6.Synonyms: IBP-6, IBP6, IGF-binding protein 6, IGFBP-6, Insulin-like growth factor-binding protein 6

Gene ID: 10090

UniProt: P47880

Pathways: WNT Signaling, Myometrial Relaxation and Contraction