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Antibodies
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anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) antibody
Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) antibody
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| Synonyms |
DOD, UBL5, D9Bwg1161e, 0610025L01Rik, dod, ubl5, pin1b, PIN1, MGC89352, pin1a, MGC132291, MGC137201 |
| Clonality |
Monoclonal (3G8) |
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Host
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Reactivity
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Application
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| Catalog no. |
ABIN361110 |
| Quantity |
50ul (1mg/ml) (Variants) |
| Price |
300.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 5 to 7 Business Days |
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Alternative name
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Pin1
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Immunogen
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Recombinant Pin1, Accession / GI number: NP_006212
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Isotype
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TBD, kappa chain
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Clone
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3G8
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Description
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Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation. Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA ,PLK I, Wee, and Myt1 kinases), several transcription factors like beta-Catenin, c-Jun, and the tumor suppressor protein p53 , and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1. Synonyms: DOD, UBL5
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Application Notes
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Recommended dilution 1:500
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Concentration
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1mg/ml
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Purification
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The antibody was purified from mouse ascitic fluids by protein-G affinity chromatography
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Buffer
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In Phosphate-Buffered Saline (pH7.4) with 0.1% Sodium Azide
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Storage
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Store at -20°, Aliquot to avoid repeated freezing and thawing.
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Research Area
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Cell Cycle
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Restrictions
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For Research Use only
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Alternatives for antigen "Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1)", type "Antibodies"
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Hosts
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Rabbit (30), Mouse (16), Chicken (5), Goat (4)
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Reactivities
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Human (50), Mouse (Murine) (26), Rat (Rattus) (26), Dog (Canine) (8), Cow (Bovine) (6), Pig (Porcine) (4), Rabbit (4), Chicken (2), Horse (Equine) (2), Monkey (1)
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Applications
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Western Blotting (WB) (37), Immunofluorescence (IF) (24), Flow Cytometry (FACS) (19), ELISA (18), Enzyme Immunoassay (EIA) (11), Immunoprecipitation (IP) (6), Immunocytochemistry (ICC) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2), Immunoelectron Microscopy (IEM) (1)
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Conjugates
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Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
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Alternatives 
