PPM1A antibody (AA 1-382)

Catalog No. ABIN361111

This Mouse Monoclonal antibody specifically detects PPM1A in WB, ELISA, IF and ICC. It exhibits reactivity toward Human.

Quick Overview for PPM1A antibody (AA 1-382) (ABIN361111)

Target: PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PPM1A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: P6c7

Product Details anti-PPM1A Antibody

Binding Specificity: AA 1-382

Purpose: Human PP2C alpha/PPM1A antibody

Purification: Purified

Immunogen: Recombinant human PP2Calpha (1-382aa) purified from E. coli

Isotype: IgG2b kappa

Application Details

Application Notes: Recommended dilution 1:250

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing cycles

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Target Details for PPM1A

Target: PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))

Alternative Name: PP2C alpha/PPM1A

Background: Protein phosphatase 2C (PP2Calpha) is a Mn2+ - or Mg 2+ -dependent protein serine/threonine phosphatase that inhibits the human stress-responsive p38 and JNk MAPk pathways and regulates cellular stress response in eukaryotes. The PPM (metal-dependent protein phosphatase) family of Ser/Thr protein phosphatases have recently been shown to down-regulate the stress response pathways in eukaryotes. Within the stress pathway, key signaling kinases, which are activated by protein phosphorylation, have been proposed as the in vivo substrates of PP2Calpha, the prototypical member of the PPM family.

NCBI Accession: NP_066283