Rhodopsin (RHO) antibody

Antigen: Rhodopsin (RHO)

Synonyms: RP4, OPN2, CSNBAD1, MGC138309, MGC138311, Rh, RH1, zfo2, zfrho, fi06d11, wu:fi06d11, CG5279, Dm Rh5, DMELRH5, DmelCG5279, rh5, RH5, DMELRH4, Dm Rh4, FBgn0003250, RH4, DmelCG9668, CG9668, CG5192, Dm Rh6, DMELRH6, DmelCG5192, R8, rh6, RH6, 143283_at, 1F9, BEST:GH11778, DMELRH1, Dm Rh1, DmRh1, FBgn0002940, Nina E, R, Rh1/ninaE, opsin, ora, rhodopsin, DmelCG4550, CG4550, DMELRH3, Dm Rh3, FBgn0003249, RH3, DmelCG10888, CG10888, Ops, Opn2, Noerg1, MGC21585, MGC25387, rho, MGC64248, PRA1, CHK-1, RHO, PIGRHO1, ops, RDP1, rp4, opn2, xrho, kfh-rh

Clonality: Monoclonal (1D4)

Host: Mouse

Reactivity: Mammalian, Amphibian

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Catalog no.: ABIN361366

Additional Information

Alternative name: Rhodopsin

Isotype: IgG1  (Matching secondary antibodies)

Clone: 1D4

Description: Rhodopsin is a photoreceptor protein found in retinal rods. It is a complex formed by the binding of retinaldehyde, the oxidized form of retinol, to the protein opsin and undergoes a series of complex reactions in response to visible light resulting in the transmission of nerve impulses to the brain. Mutation of the rhodopsin gene is a major contributor to various retinopathies such as retinitis pigmentosa. The disease-causing protein generally aggregates with ubiquitin in inclusion bodies, disrupts the intermediate filament network and impairs the ability of the cell to degrade non-functioning proteins which leads to photoreceptor apoptosis (Berson et al., 1991). Other mutations on rhodopsin lead to X-linked congenital stationary night blindness, mainly due to constitutive activation, when the mutations occur around the chromophore binding pocket of rhodopsin (Dryja et al.,1993). Several other pathological states relating to rhodopsin have been discovered including poor post-Golgi trafficking, dysregulative activation, rod outer segment instability and arrestin binding. Anti-Rhodopsin Immunohistochemical staining of mouse retinal section showing specific immunolabeling of the rhodopsin protein in the rod spherules. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA.

Specificity: Specific for the ~ 39k rhodopsin protein.

Synonyms: RP4, OPN2, CSNBAD1, MGC138309, MGC138311, Rh, RH1, zfo2, zfrho, fi06d11, wu:fi06d11, CG5279, Dm Rh5, DMELRH5, DmelCG5279, rh5, RH5, DMELRH4, Dm Rh4, FBgn0003250, RH4, DmelCG9668, CG9668, CG5192, Dm Rh6, DMELRH6, DmelCG5192, R8, rh6, RH6, 143283_at, 1F9, BEST:GH11778, DMELRH1, Dm Rh1, DmRh1, FBgn0002940, Nina E, R, Rh1/ninaE, opsin, ora, rhodopsin, DmelCG4550, CG4550, DMELRH3, Dm Rh3, FBgn0003249, RH3, DmelCG10888, CG10888, Ops, Opn2, Noerg1, MGC21585, MGC25387, rho, MGC64248, PRA1, CHK-1, RHO, PIGRHO1, ops, RDP1, rp4, opn2, xrho, kfh-rh

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 IHC: 1:100 Quality Control: Western blots performed on each lot.

Purification: Protein G purified culture supernatant.

Storage: Store at -20 °C, stable for 1 year

Research Area: Neurology

Restrictions: For Research Use only

Images

Immunohistochemical staining of mouse retinal section showing specific immunolabeling of the rhodopsin protein in the rod spherules. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA.