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Collagen, Type I, 1 Propeptide Sequence antibody
| Antigen | Collagen, Type I, 1 Propeptide Sequence |
| Clonality | Polyclonal |
| Host |
Rabbit |
| Reactivity |
Human, Mouse (Murine) |
| Application |
Western Blotting (WB), Immunohistochemistry (IHC)
|
| Catalog no. | ABIN361374 |
| Quantity | 100 µl |
| Price | 345.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 5 to 7 Business Days |
Additional Information
| Alternative name | Collagen I (1 Propeptide Sequence |
| Description | Collagen is the most abundant protein in mammals with type 1 collagen being the most abundant of the 29 known collagens. Type 1 collagen is integral in the strengthening and structural support of many tissues including skin, tendon, artery walls, fibrocartilage, bone and teeth. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the fist 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procoallagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005). Anti-Collagen I 1, propeptide |
| Specificity | Specific for the ~180 kDa collagen I (1 propeptide in human lung fibroblast extract. The antibody also works well for immunohistochemistry on paraformaldehyde-fixed sections with a simple antigen-retrieval protocol (incubate slides for 20 minutes at 90º C in 10 mM sodium citrate (pH 6.0)/ 0.1 % Tween-20). Note that in paraffin sections of formaldehyde-fixed fibrotic mouse lung tissue, it recognizes collagen I molecules that are still associated with the cells in which they were synthesized. |
