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Antibody
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anti-GABA Transporter 1 GAT1
GABA Transporter 1 (GAT1) antibody
| Antigen |
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| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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 Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
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| Catalog no. |
ABIN361450 |
| Quantity |
100 µl |
| Price |
345.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 5 to 7 Business days |
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Alternative name
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GABA Transporter (GAT) 1
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Format
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Affinity-purified
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Description
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Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003). Anti-GAT1 Western blot of rat hippocampal homogenate showing specific immunolabeling of the~ 67k GAT-1 protein.
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Specificity
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Specific for the ~67k GAT-1 protein. Immunolabeling is blocked by the peptide used as antigen.
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Application Notes
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Recommended Dilution: WB: 1:1000 IHC: 1:100-1:200 Quality Control: Western blots performed on each lot.
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Purification
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Prepared from rabbit serum by affinity purification.
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Storage
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Store at -20 °C, stable for 1 year
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Restrictions
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For Research Use only
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Alternatives for antigen "GABA Transporter 1 (GAT1)", type "Antibodies"
