NAV1.7 antibody

Antigen: NAV1.7

Clonality: Monoclonal (S68-6)

Host: Mouse

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Catalog no.: ABIN361773

Additional Information

Characteristics: Detects ~230kDa. No cross-reactivity against other Nav channels.

Gene ID: 6335

Swiss-Prot: Q15858

Immunogen: Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7, accession number Q15858

Format: Liquid

Isotype: IgG1  (Matching secondary antibodies)

Clone: S68-6

Description: Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals (3-5).
Synonyms: ETHA, hNE Na, NE NA, PN1, SCN9A, voltage gated sodium channel subunit alpha Nav1, peripheral sodium channel 1, neuroendocrine sodium channel

Specificity: ~230kDa. No cross reactivity against other Nav channels. Species cross-reactivity: Human, Mouse, Rat.

Sensitivity: 1 µg/mL of SMC-314 was sufficient for detection of Nav1.7 in 10µg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Application Details

Application Notes: 1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)

Concentration: 1 mg/mL

Purification: Protein G Purified

Buffer: PBS pH7.4, 50% glycerol

Storage: -20 °C

Storage Shipping Temp Max: Blue Ice or 4 °C

Restrictions: For Research Use only

Images

Nav1.7 (S68-6) in T-CHO

Nav1.7 (S68-6), Mouse brain tissue, Amplifier

Nav1.7 (S68-6), Human hippocampus

Publications

Publications: Dray, Read: "Arthritis and pain. Future targets to control osteoarthritis pain." in: Arthritis research & therapy, Vol. 9, Issue 3, pp. 212, 2007 (PubMed).

Dray: "Neuropathic pain: emerging treatments." in: British journal of anaesthesia, Vol. 101, Issue 1, pp. 48-58, 2008 (PubMed).

Samuels, te Morsche, Lynch et al.: "Compound heterozygosity in sodium channel Nav1.7 in a family with hereditary erythermalgia." in: Molecular pain, Vol. 4, pp. 21, 2008 (PubMed).