SCN9A antibody (AA 1751-1946)

Catalog No. ABIN361773

Cited in 1 publication. The Mouse Monoclonal anti-SCN9A antibody (Clone N68-6 (Formerly S68-6)) (ABIN361773) specifically detects SCN9A in IHC, WB, IF, IP, ICC and AA. The antibody is reactive with Human samples.

Quick Overview for SCN9A antibody (AA 1751-1946) (ABIN361773)

Target: SCN9A (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SCN9A antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Antibody Array (AA)

Clone: N68-6 (Formerly S68-6)

Product Details anti-SCN9A Antibody

Binding Specificity: AA 1751-1946

Specificity: Detects ~230 kDa. No cross-reactivity against other Nav channels.

Cross-Reactivity: Hamster, Human, Mouse, Rat

Purification: Protein G Purified

Immunogen: Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7

Isotype: IgG1

Application Details

Application Notes:

• WB (1:1000)
• IHC (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Comment:

1 μg/ml of ABIN361773 was sufficient for detection of Nav1.7 in 10 μg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C

References for anti-SCN9A antibody (ABIN361773)

Ngwainmbi, De, Smith, El-Hage, Fitting, Kang, Dewey, Hauser, Akbarali: "Effects of HIV-1 Tat on enteric neuropathogenesis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 43, pp. 14243-51, (2014) (PubMed).

Target Details for SCN9A

Target: SCN9A (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A))

Alternative Name: Nav1.7

Background: Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals (1-3).

Gene ID: 6335

NCBI Accession: NP_002968

UniProt: Q15858