Calreticulin (CALR) antibody

Antigen: Calreticulin (CALR)

Synonyms: RO, CRT, SSA, cC1qR, FLJ26680, crc, MGC52637, Crt, crt, Calregulin, zgc:85636, Clr, anon-EST:Liang-2.11, anon-EST:Liang-2.17, anon-EST:fe3D7, clone 2.11, clone 2.17, eth, potp, DmelCG9429, CG9429, ssa, cc1qr, MGC69541, CALR, NV19007

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Chicken, Guinea Pig, Monkey, Pig (Porcine), Hamster, Rabbit, Sheep (Ovine)

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Catalog no.: ABIN361834

Additional Information

Alternative name: Calreticulin

Immunogen: Human calreticulin synthetic peptide with a cysteine residue added and the peptide conjugated to KLH

Format: Antiserum

Description: Calreticulin is a multifunctional, highly conserved Ca2+ -binding protein that is localized to the endoplasmic reticulum (ER), but has also been detected in the nucleus and nuclear envelop. Like many other ER proteins, it has the conserved ER retention KDEL (Lys-Asp-Glu-Leu) sequence at its C-terminus (1-3). CRT

Specificity: Detects ~63kDa Species Cross-Reactivity Human, mouse, rat, bovine, canine, chicken, guinea pig, monkey, pig, hamster, rabbit , sheep

Synonyms: RO, CRT, SSA, cC1qR, FLJ26680, crc, MGC52637, Crt, crt, Calregulin, zgc:85636, Clr, anon-EST:Liang-2.11, anon-EST:Liang-2.17, anon-EST:fe3D7, clone 2.11, clone 2.17, eth, potp, DmelCG9429, CG9429, ssa, cc1qr, MGC69541, CALR, NV19007

Application Details

Application Notes: Working Dilution WB 1:5000-10000 (ECL, human)

Buffer: Whole Rabbit serum

Storage: -20°C, 1 year+, shipped on cold packs

Research Area: Signaling, Organelles, Autophagy

Restrictions: For Research Use only

Images

Calreticulin, Mouse backskin

Publications

Publications: Smith, Koch: "Multiple zones in the sequence of calreticulin (CRP55, calregulin, HACBP), a major calcium binding ER/SR protein." in: The EMBO journal, Vol. 8, Issue 12, pp. 3581-6, 1990 (PubMed).

Nash, Opas, Michalak: "Calreticulin: not just another calcium-binding protein." in: Molecular and cellular biochemistry, Vol. 135, Issue 1, pp. 71-8, 1995 (PubMed).

Krause, Michalak: "Calreticulin." in: Cell, Vol. 88, Issue 4, pp. 439-43, 1997 (PubMed).

Wada, Kai, Imai et al.: "Promotion of transferrin folding by cyclic interactions with calnexin and calreticulin." in: The EMBO journal, Vol. 16, Issue 17, pp. 5420-32, 1997 (PubMed).

Heal, McGivan: "Induction of calreticulin expression in response to amino acid deprivation in Chinese hamster ovary cells." in: The Biochemical journal, Vol. 329 ( Pt 2), pp. 389-94, 1998 (PubMed).

Laquerre, Anderson, Argnani et al.: "Herpes simplex virus type 1 glycoprotein B requires a cysteine residue at position 633 for folding, processing, and incorporation into mature infectious virus particles." in: Journal of virology, Vol. 72, Issue 6, pp. 4940-9, 1998 (PubMed).

Lucero, Kaminer: "The role of calcium on the activity of ERcalcistorin/protein-disulfide isomerase and the significance of the C-terminal and its calcium binding. A comparison with mammalian protein-disulfide isomerase." in: The Journal of biological chemistry, Vol. 274, Issue 5, pp. 3243-51, 1999 (PubMed).

Yoon, Lee, Jung et al.: "Nuclear matrix of calreticulin in hepatocellular carcinoma." in: Cancer research, Vol. 60, Issue 4, pp. 1117-20, 2000 (PubMed).

Johnson, Michalak, Opas et al.: "The ins and outs of calreticulin: from the ER lumen to the extracellular space." in: Trends in cell biology, Vol. 11, Issue 3, pp. 122-9, 2001 (PubMed).

Ellgaard, Helenius: "ER quality control: towards an understanding at the molecular level." in: Current opinion in cell biology, Vol. 13, Issue 4, pp. 431-7, 2001 (PubMed).

Antoniou, Ford, Pilley et al.: "Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits." in: Immunology, Vol. 106, Issue 2, pp. 182-9, 2002 (PubMed).

Tanaka, Tanaka, Tokuhara et al.: "Amyloid fibril formation and chaperone-like activity of peptides from alphaA-crystallin." in: Biochemistry, Vol. 47, Issue 9, pp. 2961-7, 2008 (PubMed).