ABL1/2 antibody (AA 391-395)

Catalog No. ABIN363101

The Rabbit Polyclonal anti-ABL1/2 antibody is suitable to detect ABL1/2 in samples from Human and Mouse. It has been validated for IHC and IF.

Quick Overview for ABL1/2 antibody (AA 391-395) (ABIN363101)

Target: ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABL1/2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-ABL1/2 Antibody

Binding Specificity: AA 391-395

Specificity: The antibody detects endogenous levels of total ABL1/2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen. Specificity/Sensitivity ABL1/2 (Ab-393/429) Antibody detects endogenous levels of total ABL1/2 protein.

Immunogen: Peptide sequence around AA 391-395, 427-431 (D-T-Y-T-A) derived from ABL1, 2 Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Isotype: IgG

Application Details

Application Notes: Western blotting: 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for ABL1/2

Target: ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))

Alternative Name: ABL1/2

Background: Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Molecular Weight: 210 kDa

NCBI Accession: NP_001129, NP_005148

UniProt: P42684