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Details for Product No. ABIN370999

CD72 Molecule (CD72) antibody (Biotin)

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Antigen
Synonyms LYB2, CD72b
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Biotin
Application
»Alternatives Flow Cytometry (FACS)
Pubmed 5 references available
Catalog no. ABIN370999
Quantity 0.5 mg
Price
401.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen DBA/2 mouse spleen cells. (Ref. 1)
Clone 10-1-D-2
Isotype IgG2b
Characteristics Synonyms: Lyb-2, Ly-32, Ly32, B-Cell marker, B-cell differentiation antigen CD72, Lymphocyte antigen32
Alternative Name CD72
Background Murine CD72. 1/Lyb-2. 1, a type II integral membrane glycoprotein and a member of theC-lectin family of cell surface receptors, is a differentiation antigen of B cells, and is foundin mouse strains expressing the Lyb-2. 1 allotype. CD72. 1 is the ligand of CD5 (Ly-1) which isdistributed on all T cells and a small number of B cells. (Ref. 1,2)This clone blocks binding of CD5 to CD72 on the B cell surface, which leads to inhibition ofthe positive signal resulting from CD5/CD72 pairing. (Ref. 1) However, 10-1. D. 2 can itselftrigger a positive signal by binding CD72. (Ref. 1-5)
UniProt P21855
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: < / = 1 µg/10e6 cells. (Ref.1,2)Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.09% Sodium Azide as preservative.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Beavil, Edmeades, Gould et al.: "Alpha-helical coiled-coil stalks in the low-affinity receptor for IgE (Fc epsilon RII/CD23) and related C-type lectins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 2, pp. 753-7, 1992 (PubMed).

Luo, Van de Velde, von Hoegen et al.: "Ly-1 (CD5), a membrane glycoprotein of mouse T lymphocytes and a subset of B cells, is a natural ligand of the B cell surface protein Lyb-2 (CD72)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 6, pp. 1630-4, 1992 (PubMed).

Snow, Mond, Subbarao: "Enhancement by monoclonal anti-Lyb-2 antibody of antigen-specific B lymphocyte expansion stimulated by TNP-Ficoll and T lymphocyte-derived factors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 137, Issue 6, pp. 1793-6, 1986 (PubMed).

Subbarao, Mosier: "Induction of B lymphocyte proliferation by monoclonal anti-Lyb 2 antibody." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 130, Issue 5, pp. 2033-7, 1983 (PubMed).

Robinson, Landolfi, Schäfer et al.: "Biochemical identity of the mouse Ly-19.2 and Ly-32.2 alloantigens with the B cell differentiation antigen Lyb-2/CD72." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 9, pp. 4764-72, 1993 (PubMed).

Alternatives for antigen "CD72 Molecule (CD72)", type "Antibodies"
Hosts (92), (23), (1)
Reactivities (78), (35)
Applications (76), (26), (25), (12), (9), (4), (4), (3), (2), (1), (1)
Conjugates (20), (15), (15)
Epitopes (4), (3), (3), (2), (2), (1), (1), (1), (1)
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