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CD72 Molecule (CD72) antibody (FITC)

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Synonyms CD72c, Ly-19, Ly-32, Ly-m19, Lyb-2, CD72b, LYB2
Mouse (Murine)
(110), (32), (7)
(85), (56), (1), (1)
Clonality (Clone)
Monoclonal ()
(20), (16), (13), (3), (3), (3), (1)
Flow Cytometry (FACS)
(63), (55), (48), (23), (11), (9), (4), (3), (2), (2), (2), (2), (1)
Pubmed 5 references available
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Quantity 0.5 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen DBA/2 mouse spleen cells. (Ref. 1)
Clone 10-1-D-2
Isotype IgG2b
Specificity This antibody recognises CD72.1/Lyb-2.1 (Mr. 45 kDa).
Characteristics Synonyms: Lyb-2, Ly-32, Ly32, B-Cell marker, B-cell differentiation antigen CD72, Lymphocyte antigen32
Alternative Name CD72 (CD72 Antibody Abstract)
Background Murine CD72.1/Lyb-2.1, a type II integral membrane glycoprotein and a member of the C-lectin family of cell surface receptors, is a differentiation antigen of B cells, and is found in mouse strains expressing the Lyb-2.1 allotype. CD72.1 is the ligand of CD5 (Ly-1) which is distributed on all T cells and a small number of B cells. (Ref.1,2) This clone blocks binding of CD5 to CD72 on the B cell surface, which leads to inhibition of the positive signal resulting from CD5/CD72 pairing. (Ref.1) However, 10-1.D.2 can itself trigger a positive signal by binding CD72. (Ref.1-5)Synonyms: B-Cell marker, B-cell differentiation antigen CD72, Ly-32, Ly32, Lyb-2, Lymphocyte antigen 32
Gene ID 100504743
UniProt P21855
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: < / = 1 μg/10^6 cells. (Ref.1,2)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-CD72 Molecule (CD72) antibody (FITC) (ABIN371000) anti-CD72 Molecule (CD72) antibody (FITC)
Background publications Robinson, Landolfi, Schäfer et al.: "Biochemical identity of the mouse Ly-19.2 and Ly-32.2 alloantigens with the B cell differentiation antigen Lyb-2/CD72." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 9, pp. 4764-72, 1993 (PubMed).

Subbarao, Mosier: "Induction of B lymphocyte proliferation by monoclonal anti-Lyb 2 antibody." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 130, Issue 5, pp. 2033-7, 1983 (PubMed).

Snow, Mond, Subbarao: "Enhancement by monoclonal anti-Lyb-2 antibody of antigen-specific B lymphocyte expansion stimulated by TNP-Ficoll and T lymphocyte-derived factors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 137, Issue 6, pp. 1793-6, 1986 (PubMed).

Luo, Van de Velde, von Hoegen et al.: "Ly-1 (CD5), a membrane glycoprotein of mouse T lymphocytes and a subset of B cells, is a natural ligand of the B cell surface protein Lyb-2 (CD72)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 6, pp. 1630-4, 1992 (PubMed).

Beavil, Edmeades, Gould et al.: "Alpha-helical coiled-coil stalks in the low-affinity receptor for IgE (Fc epsilon RII/CD23) and related C-type lectins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 2, pp. 753-7, 1992 (PubMed).

Catalog No. ABIN371000
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