Integrin beta 7 antibody (Biotin)

Catalog No. ABIN371133

This anti-Integrin beta 7 antibody is a Rat Monoclonal antibody detecting Integrin beta 7 in FACS. Suitable for Mouse.

Quick Overview for Integrin beta 7 antibody (Biotin) (ABIN371133)

Target: Integrin beta 7 (ITGB7)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Integrin beta 7 antibody is conjugated to Biotin

Application: Flow Cytometry (FACS)

Clone: DATK32

Product Details anti-Integrin beta 7 Antibody (Biotin)

Specificity: This antibody is specific to mouse LPAM1 (Integrin alpha 4 beta 7). It recognises a conformational epitope on the heterodimer.

Characteristics: Synonyms: Integrin beta-P, M290 IEL antigen, ITGB7, LPAM-1, LPAM1, Lymphocyte Peyer PatchAdhesion Molecule

Immunogen: AKR/Cum mouse spontaneous T lymphoma cell line TK1. (Ref. 1)

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry: < / = 1 μg/10^6 cells. (Ref.1-4)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or in (aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Integrin beta 7

Target: Integrin beta 7 (ITGB7)

Alternative Name: Integrin beta-7

Background: The lymphocyte Peyer's patch adhesion molecule (LPAM-1), also known as Integrin alpha 4 beta 7 is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria. (Ref.1-4) The Monoclonal antibody DATK32 has been shown to be useful for studies of the induction of homotypic cellular aggregation and the blockade of binding to cell adhesion molecules. (Ref.1)Synonyms: Adhesion Molecule, ITGB7, Integrin beta-P, LPAM-1, LPAM1, Lymphocyte Peyer Patch, M290 IEL antigen

Gene ID: 16421

UniProt: P26011

Pathways: Integrin Complex