Lysosomal-Associated Membrane Protein 2 (LAMP2) antibody (FITC)

Details for Product No. ABIN371201
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Antigen
Synonyms cd107b, lamp-2, lampb, LAMP2, lamp2, DKFZp459J126, LAMP-2, LGP-B, CD107b, Lamp-2, Lamp-2a, Lamp-2b, Lamp-2c, Mac3, LAMPB, LGP110
Reactivity
Mouse (Murine)
(121), (116), (24), (19), (13), (13), (7), (2)
Host
Rat
(85), (83), (52), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
FITC
(29), (21), (14), (11), (5), (5), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(100), (93), (54), (52), (47), (41), (30), (28), (28), (10), (2), (2), (2), (1)
Pubmed 5 references available
Quantity 0.5 mg
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Catalog No. ABIN371201
357.50 $
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Immunogen Glycoproteins purified from BALB/c mouse embryo 3T3 cell line. (Ref. 1)
Clone ABL-93
Isotype IgG2a
Specificity This antibody is specific to CD107b/LAMP-2 (Mr 110-120 kDa with a core protein of Mr ~40 kDa).
Characteristics Synonyms: LAMP-2, LAMP-2C, LAMPB, Lysosome-associated membrane glycoprotein 2
Alternative Name CD107b / LAMP2
Background CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated, type I transmembrane protein that constitutes one of the two major sialoglycoproteins on lysosomal membranes that can be used to distinguish lysosomes from other organelles. (Ref.1) CD107b is similar in structure to Mac-1 and is expressed primarily on epithelial cells and macrophages in a variety of organs in normal and Beige mutant mice. (Ref.2)Synonyms: LAMP-2, LAMP-2C, LAMPB, Lysosome-associated membrane glycoprotein 2
Gene ID 16784
UniProt P17047
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: < / = 1 μg/10^6 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or in (aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Fukuda: "Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking." in: The Journal of biological chemistry, Vol. 266, Issue 32, pp. 21327-30, 1991 (PubMed).

Chen, Chen, DSouza et al.: "Lysosomal membrane glycoproteins: properties of LAMP-1 and LAMP-2." in: Biochemical Society symposium, Vol. 51, pp. 97-112, 1987 (PubMed).

Chen, Pan, DSouza et al.: "Lysosome-associated membrane proteins: characterization of LAMP-1 of macrophage P388 and mouse embryo 3T3 cultured cells." in: Archives of biochemistry and biophysics, Vol. 239, Issue 2, pp. 574-86, 1985 (PubMed).

Kannan, Stewart, Bounds et al.: "Lysosome-associated membrane proteins h-LAMP1 (CD107a) and h-LAMP2 (CD107b) are activation-dependent cell surface glycoproteins in human peripheral blood mononuclear cells which mediate cell adhesion to vascular endothelium." in: Cellular immunology, Vol. 171, Issue 1, pp. 10-9, 1996 (PubMed).

Furuta, Yang, Chen et al.: "Differential expression of the lysosome-associated membrane proteins in normal human tissues." in: Archives of biochemistry and biophysics, Vol. 365, Issue 1, pp. 75-82, 1999 (PubMed).

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