CD8B antibody (PE)

Catalog No. ABIN371370

Product Details anti-CD8B Antibody (PE)

Target: CD8B (CD8b Molecule (CD8B))

Reactivity: Chicken

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD8B antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Specificity: This antibody recognizes beta chain of Chicken CD8 (Mr. 34 kDa).

Characteristics: Synonyms: eu2, Ly3, LYT3, CD8B1, T cell surface glycoprotein CD8 beta chain

Clone: EP42

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry: < / = 0.2 μg/10^6 cells. (Ref.2)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative and a stabilizing agent.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CD8B

Target: CD8B (CD8b Molecule (CD8B))

Alternative Name: CD8 beta (CD8B Products)

Background: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. Chicken CD8 is expressed on approximately 80 % of thymocytes, 45 % of blood mononuclear cells and 50 % of spleen cells, but <1 % of cells in the bursa and bone marrow. (Ref.1,2)Synonyms: CD8B, CD8B1, T-cell surface glycoprotein CD8 beta chain

Gene ID: 396175

UniProt: Q90769

Pathways: TCR Signaling