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Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 100-150) antibody
| Antigen | Lysine (K)-Specific Demethylase 1A (KDM1A) |
| Synonyms | AOF2, KDM1, LSD1, BHC110, KIAA0601, RP1-184J9.1, Aof2, Lsd1, AA408884, mKIAA0601, D4Ertd478e, 1810043O07Rik, RGD1562975, aof2, wu:fj36a05, KDM1A, DKFZp459N2450, kdm1, lsd1, xLSD1 |
| Epitope |
 Alternatives AA 100-150 |
| Clonality | Polyclonal |
| Host |
Alternatives Rabbit |
| Reactivity |
Alternatives Dog (Canine) |
| Application |
Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|
| Catalog no. | ABIN372401 |
| Quantity | 50 µg (0.5 mg/ml) |
| Price | 390.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Characteristics | Synonyms: Lysine-specific histone demethylase 1, KIAA0601, LSD1, Flavin-containing amine oxidasedomain-containing protein 2, BRAF35-HDAC complex protein BHC110 |
| Alternative name | AOF2 |
| Swiss-Prot | O60341 |
| Immunogen | Synthetic peptide corresponding to a portion of amino acids of human AOF2. Remarks: Antigen Modification: aa100-150 |
| Cross-Reactivity | Dog (Canine), Human, Monkey, Mouse (Murine), Rat (Rattus) |
| Isotype | IgG (Matching secondary antibodies) |
| Description | LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, aspecific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. Thisprotein is a component of several histone deacetylase complexes, though it silences genesby functioning as a histone demethylase. It acts by oxidizing the substrate by FAD togenerate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylatesboth mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in therepression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' onnucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It mayalso demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptionalrepression, thereby leading to derepression of androgen receptor target genes. |
| Specificity | This antibody recognizes Amine Oxidase (Flavin Containing) Domain 2 (AOF2/KDM1A). Species Reactivity: Tested: Human. Expected from sequence similarity: Dog (Canine), Macaque, Monkey, Mouse, Rat andZebrafish. Add. Information: Predicted Molecular Weight: 93 kDa. |
Application Details
| Application Notes | Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western blot: 0.5-2 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. |
| Concentration | 0.5 mg/ml |
| Purification | Aff - Purified |
| Buffer | PBS containing 0.2% Gelatin as stabilizer and 0.05% Sodium Azide aspreservative. |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "Lysine (K)-Specific Demethylase 1A (KDM1A)", type "Antibodies"
| Hosts | Rabbit (19), Mouse (7) |
| Reactivities | Human (26), Mouse (Murine) (3), Rat (Rattus) (2) |
| Applications | Western Blotting (WB) (25), Enzyme Immunoassay (EIA) (13), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (12), ELISA (4), Immunohistochemistry (IHC) (3), ELISA (Detection) (2), Immunoprecipitation (IP) (2), Chromatin Immunoprecipitation (ChiP) (1), Dot Blot (Dot) (1), Immunoassay (IA) (1), Immunocytochemistry (ICC) (1), Immunofluorescence (IF) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1) |
| Epitopes | N-Term (4), C-Term (2), Center (2), internal (1) |
