RDH11 antibody (C-Term, N-Term)

Catalog No. ABIN372579

The Rabbit Polyclonal anti-RDH11 antibody (ABIN372579) specifically detects RDH11 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for RDH11 antibody (C-Term, N-Term) (ABIN372579)

Target: RDH11 (Retinol Dehydrogenase 11 (All-Trans/9-Cis/11-Cis) (RDH11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RDH11 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-RDH11 Antibody

Binding Specificity: AA 1-7, C-Term, N-Term

Specificity: Recognizes Retinol Dehydrogenase 11 (all-trans/9-cis/11-cis) (RDH11).
Cellular Localization: Endoplasmic reticulum membrane, Single-pass type II membrane protein.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide - KLH conjugated corresponding to N-terminal sequence MVELMFP (aa 1-7) and the C-terminal sequence LLGLPID (312-318) of the Human RDH11.

Isotype: IgG

Application Details

Application Notes: Western Blot: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for RDH11

Target: RDH11 (Retinol Dehydrogenase 11 (All-Trans/9-Cis/11-Cis) (RDH11))

Alternative Name: RDH11

Background: RDH11 (Retinol dehydrogenase 11) exhibits an oxidoreductive catalytic activity towards retinoids. RDH11 is most efficient as an NADPH-dependent all-trans-retinal reductase. RDH11 is also involved in the metabolism of short-chain aldehydes. RDH11 is located in endoplasmic reticulum and is expressed at higher level in liver and testis and is expressed at lower levels in smooth muscle, thymus, submaxillary gland and epididymis. In testis, expression is restricted to pachytene spermatocytes. RDH11 is also expressed in four layers of the retina, including the outer segment of rods and cones. RDH11 belongs to the short-chain dehydrogenases/reductases (SDR) family.Synonyms: ARSDR1, CGI-82, HCBP12, HCV core-binding protein HCBP12, PSDR1, Prostate short-chain dehydrogenase/reductase 1, RalR1, Retinal Reductase 1, Retinol Dehydrogenase 11

Molecular Weight: 35 kDa

Gene ID: 51109

NCBI Accession: NP_057110

UniProt: Q8TC12