AOC3 antibody (Internal Region)

Catalog No. ABIN372956

The Goat Polyclonal anti-AOC3 antibody is suitable to detect AOC3 in samples from Human, Mouse and Rat. It has been validated for IHC (p) and EIA.

Quick Overview for AOC3 antibody (Internal Region) (ABIN372956)

Target: AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))

Reactivity: Human, Mouse, Rat

Host: Goat

Clonality: Polyclonal

Conjugate: This AOC3 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-AOC3 Antibody

Binding Specificity: Internal Region

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide (C-DEDPSFYSADSIY) from an internal region of human AOC3

Application Details

Application Notes: Immunohistochemistry on paraffin sections: 3.75 μg/mL. ELISA: 1/64000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Tris saline buffer, pH 7.3, 0.5 % BSA, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for AOC3

Target: AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))

Alternative Name: AOC3 / VAP1

Background: VAP1, upregulated in response to inflammation, is a cell adhesion protein that participates in lymphocyte recirculation, by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells, in an L selectin independent fashion. VAP1 also displays a monoamine oxidase activity, catalyzing the deamination of methylamine to produce formaldehyde. Upregulation of VAP1 has been reported in Alzheimer's disease, where increased levels of formaldehyde are responsible for b amyloid cross linkage and plaque formation, significantly contributing to the pathogenesis of this disease.Synonyms: Copper amine oxidase, HPAO, Membrane primary amine oxidase, Semicarbazide-sensitive amine oxidase, Vascular adhesion protein 1

Gene ID: 9606

UniProt: Q16853

Pathways: Feeding Behaviour