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B-Cell Receptor-Associated Protein 31 (BCAP31) (C-Term) antibody

Details for Product No. ABIN374194, Supplier: Log in to see
Antigen
  • 6c6-ag
  • bap31
  • cdm
  • dxs1357e
  • BCAP31
  • Bap31
  • 6C6-AG
  • BAP31
  • CDM
  • DXS1357E
  • CALD1
  • caldesmon
  • si:bz30i22.4
  • si:rp71-30i22.4
  • zgc:56389
Epitope
C-Term
33
15
7
6
4
3
3
3
2
2
1
1
1
1
1
1
Reactivity
Human
130
33
31
5
4
2
2
1
1
1
1
Host
Goat
95
17
11
8
Clonality
Polyclonal
Conjugate
Un-conjugated
7
7
7
2
2
2
1
Application
Western Blotting (WB)
122
68
41
21
11
11
8
4
3
2
1
1
1
1
1
Supplier
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Immunogen Peptide from C Terminus of the protein sequence according to NP_001132929.1, NP_005736.3, NP_001132913.1. Genename: BCAP31
Sequence C-QAAVDGPMDK KEE
Specificity This antibody detects BCAP31 / BAP31 at C-term.
Purification Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Alternative Name BCAP31 / BAP31 (BCAP31 Antibody Abstract)
Background BAP31 (B Cell Receptor Associated Protein, 28 kDa) is a multiple membrane spanning protein of the endoplasmic reticulum. It has been shown to form both homo and hetero oligomers with the closely related BAP29, and is a potential apoptotic regulator as a predicted BCL2/BCLXL associated protein. In the C terminal domain of BAP31, there are two identical recognition sites for initiator Caspases 1 and 8 of the programmed death cascade. It is hypothesized that BAP31 plays a role in the transport of selected proteins to the Golgi apparatus. BAP31 has also been shown to control expression of CFTR (cystic fibrosis transmembrane conductance regulator). It is believed that interference with the expression or function of BAP31 in epithelial cells may be a way to circumvent the chloride channel defect in cystic fibrosis.Synonyms: 6C6-AG tumor-associated antigen, B-cell receptor-associated protein 31, BCR-associated protein Bap31, DXS1357E, Protein CDM, p28 Bap31
Gene ID 10134
NCBI Accession NP_001132929
UniProt P51572
Pathways
Application Notes Peptide ELISA: Limit dilution 1: 4000. Western blot: 1-3 μg/mL. Approx 30 kDa band observed in Human Placenta and Brain lysate(predicted MW of 20 kDa according to NP_005736).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
Supplier Images
 image for anti-B-Cell Receptor-Associated Protein 31 (BCAP31) (C-Term) antibody (ABIN374194) anti-B-Cell Receptor-Associated Protein 31 (BCAP31) (C-Term) antibody
Background publications Adachi, Schamel, Kim et al.: "The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence." in: The EMBO journal, Vol. 15, Issue 7, pp. 1534-41, 1996 (PubMed).