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CD2 (Cytoplasmic Tail) Binding Protein 2 (CD2BP2) (N-Term) antibody

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Synonyms FWP010, LIN1, PPP1R59, Snu40, U5-52K, 1500011B02Rik, 2410024K20Rik, AW048183
(30), (17), (2), (2), (1), (1), (1), (1), (1)
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(42), (3), (2), (2), (2), (2), (1), (1), (1)
(28), (15)
(3), (3), (3), (3), (3), (3)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(37), (33), (20), (15), (3)
Pubmed 1 reference available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide from the N Terminus of the protein sequence according to NP_006101.1.
Specificity This antibody recognizes CD2BP2.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Dog, Cow.
Species reactivity (tested):Human.
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
Alternative Name CD2BP2 (CD2BP2 Antibody Abstract)
Background CD2BP2 is an intracellular protein which binds to a site containing two PPPGHR segments within the cytoplasmic region of CD2. Mutagenesis and NMR analysis demonstrated that the CD2 binding region of CD2BP2 includes a 17 amino acid motif also found in several yeast and Caenorhabditis elegans proteins of unknown function. In Jurkat T cells, over expression of the isolated CD2BP2 domain binding to CD2 enhances the production of interleukin 2 on crosslinking of CD2 but not the T cell receptor.Synonyms: CD2 antigen cytoplasmic tail-binding protein 2, CD2 cytoplasmic domain-binding protein, CD2 tail-binding protein, KIAA1178
Gene ID 10421, 9606
UniProt O95400
Research Area Immunology, Adaptive Immunity, CD Antigens
Application Notes Peptide ELISA: 1/32,000. Western Blot: 0.3-1.0 μg/mL. Detects a band of Approx 50 kDa in Human Lymph Node,Thymus and Tonsil lysates (Predicted Molecular Weight: 37.0 kDa).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
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 image for anti-CD2 (Cytoplasmic Tail) Binding Protein 2 (CD2BP2) (N-Term) antibody (ABIN374445) anti-CD2 (Cytoplasmic Tail) Binding Protein 2 (CD2BP2) (N-Term) antibody
Background publications Nishizawa, Freund, Li et al.: "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 25, pp. 14897-902, 1999 (PubMed).

Catalog No. ABIN374445
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