CD2 (Cytoplasmic Tail) Binding Protein 2 (CD2BP2) (N-Term) antibody

Details for Product No. ABIN374445
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Antigen
Synonyms FWP010, LIN1, PPP1R59, Snu40, U5-52K, 1500011B02Rik, 2410024K20Rik, AW048183
Epitope
N-Term
(11), (9), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(17)
Host
Goat
(13), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(14), (12), (9), (9), (2)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN374445
357.50 $
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Immunogen Peptide from the N Terminus of the protein sequence according to NP_006101.1.
Sequence C-PKRKVTFQGV GDE
Specificity This antibody recognizes CD2BP2. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse and Rat.
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
Alternative Name CD2BP2
Background CD2BP2 is an intracellular protein which binds to a site containing two PPPGHR segments within the cytoplasmic region of CD2. Mutagenesis and NMR analysis demonstrated that the CD2 binding region of CD2BP2 includes a 17 amino acid motif also found in several yeast and Caenorhabditis elegans proteins of unknown function. In Jurkat T cells, over expression of the isolated CD2BP2 domain binding to CD2 enhances the production of interleukin 2 on crosslinking of CD2 but not the T cell receptor.
Alternate names: CD2 antigen cytoplasmic tail-binding protein 2, CD2 cytoplasmic domain-binding protein, CD2 tail-binding protein, KIAA1178
Gene ID 10421, 9606
UniProt O95400
Research Area Immunology, Adaptive Immunity, CD Antigens
Application Notes Peptide ELISA: 1/32,000. Western Blot: 0.3-1.0 µg/ml. Detects a band of Approx 50kDa in Human Lymph Node,Thymus and Tonsil lysates (Predicted Molecular Weight: 37.6kDa). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Supplier Images
anti-CD2 (Cytoplasmic Tail) Binding Protein 2 (CD2BP2) (N-Term) antibody anti-CD2 (Cytoplasmic Tail) Binding Protein 2 (CD2BP2) (N-Term) antibody
Background publications Nishizawa, Freund, Li et al.: "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 25, pp. 14897-902, 1999 (PubMed).

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