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CD2 (Cytoplasmic Tail) Binding Protein 2 (CD2BP2) (N-Term) antibody

Details for Product No. ABIN374445, Supplier: Log in to see
Antigen
  • FWP010
  • LIN1
  • PPP1R59
  • Snu40
  • U5-52K
  • 1500011B02Rik
  • 2410024K20Rik
  • AW048183
Epitope
N-Term
29
17
2
2
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
40
3
2
2
2
2
1
1
1
Host
Goat
27
14
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
3
3
3
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
36
31
20
15
3
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Immunogen Peptide from the N Terminus of the protein sequence according to NP_006101.1.
Sequence C-PKRKVTFQGV GDE
Specificity This antibody recognizes CD2BP2.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Dog, Cow.
Species reactivity (tested):Human.
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
Alternative Name CD2BP2 (CD2BP2 Antibody Abstract)
Background CD2BP2 is an intracellular protein which binds to a site containing two PPPGHR segments within the cytoplasmic region of CD2. Mutagenesis and NMR analysis demonstrated that the CD2 binding region of CD2BP2 includes a 17 amino acid motif also found in several yeast and Caenorhabditis elegans proteins of unknown function. In Jurkat T cells, over expression of the isolated CD2BP2 domain binding to CD2 enhances the production of interleukin 2 on crosslinking of CD2 but not the T cell receptor.Synonyms: CD2 antigen cytoplasmic tail-binding protein 2, CD2 cytoplasmic domain-binding protein, CD2 tail-binding protein, KIAA1178
Gene ID 10421, 9606
UniProt O95400
Research Area Immunology, Adaptive Immunity, CD Antigens
Pathways
Application Notes Peptide ELISA: 1/32,000. Western Blot: 0.3-1.0 μg/mL. Detects a band of Approx 50 kDa in Human Lymph Node,Thymus and Tonsil lysates (Predicted Molecular Weight: 37.0 kDa).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
 image for anti-CD2 (Cytoplasmic Tail) Binding Protein 2 (CD2BP2) (N-Term) antibody (ABIN374445) anti-CD2 (Cytoplasmic Tail) Binding Protein 2 (CD2BP2) (N-Term) antibody
Background publications Nishizawa, Freund, Li et al.: "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 25, pp. 14897-902, 1999 (PubMed).