DCP1A antibody (C-Term)

Catalog No. ABIN374653

This Goat Polyclonal antibody specifically detects DCP1A in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for DCP1A antibody (C-Term) (ABIN374653)

Target: DCP1A (DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) (DCP1A))

Reactivity: Human, Mouse, Rat

Host: Goat

Clonality: Polyclonal

Conjugate: This DCP1A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DCP1A Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to DCP1A.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogen: Peptide with sequence C-QVLTKNKDNHN, from the C Terminus of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/4000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for DCP1A

Target: DCP1A (DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) (DCP1A))

Alternative Name: DCP1A

Background: Dcp1a is necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Dcp1a binds DCP1B, DCP2, RENT1 and SMAD4 and forms part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1.Synonyms: SMIF, Smad4-interacting transcriptional co-activator, Transcription factor SMIF, mRNA-decapping enzyme 1A

Gene ID: 55802, 9606

UniProt: Q9NPI6