Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (Internal Region) antibody

Details for Product No. ABIN374681
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Antigen
Synonyms
CAP102, Catna1, AA517462, AI988031, 2010010M04Rik, CG17947, CT39986, Dalpha-Cat, Dalpha-cat, DalphaC, Dalphacat, Dmcatp, Dmel\\CG17947, a-Cat, a-cat, alpha-CAT, alpha-cat, alpha-catenin, alpha-ctn, al ... show more
CAP102, Catna1, AA517462, AI988031, 2010010M04Rik, CG17947, CT39986, Dalpha-Cat, Dalpha-cat, DalphaC, Dalphacat, Dmcatp, Dmel\\CG17947, a-Cat, a-cat, alpha-CAT, alpha-cat, alpha-catenin, alpha-ctn, alphaCAT, alphaCat, alphacat, Alpha-Cat, dgri_GLEANR_3829, DgriGH19548, GH19548 show less
Epitope
Internal Region
(32), (29), (6), (4), (3), (1), (1), (1), (1)
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(110), (72), (49), (27), (24), (24), (12), (3), (2)
Host
Goat
(99), (12), (5), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(92), (42), (27), (23), (20), (13), (10), (9), (3), (2), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN374681
Quantity 0.1 mg
Price
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Immunogen Peptide with sequence C-KREKQDETQTKIK, from the internal region of the protein sequence
Specificity This antibody reacts to Catenin alpha-1 / CTNNA1. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat, Canine.
Purification Affinity chromatography
Alternative Name Catenin alpha-1 / CTNNA1
Background The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell- adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.
Alternate names: Alpha Catenin, Alpha E-catenin, Cadherin-associated protein, NY-REN-13 antigen
Gene ID 1495
NCBI Accession 9606
UniProt P35221
Research Area Signaling
Application Notes Peptide ELISA: 1/32000. Western Blot: 1 - 3 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (Internal Region) antibody anti-Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1) (Internal Region) antibody
Background publications Troncone, Anderson, Herrington et al.: "Comparative analysis of human papillomavirus detection by dot blot hybridisation and non-isotopic in situ hybridisation." in: Journal of clinical pathology, Vol. 45, Issue 10, pp. 866-70, 1992 (PubMed).

Lynch, Grady, Suriano et al.: "Gastric cancer: new genetic developments." in: Journal of surgical oncology, Vol. 90, Issue 3, pp. 114-33; discussion 133, 2005 (PubMed).

Hosts (99), (12), (5), (2)
Reactivities (110), (72), (49), (27), (24), (24), (12), (3), (2)
Applications (92), (42), (27), (23), (20), (13), (10), (9), (3), (2), (1), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (32), (29), (6), (4), (3), (1), (1), (1), (1)
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