OGG1 antibody (Internal Region)

Catalog No. ABIN374768

The Goat Polyclonal anti-OGG1 antibody has been validated for WB. It is suitable to detect OGG1 in samples from Mouse and Rat.

Quick Overview for OGG1 antibody (Internal Region) (ABIN374768)

Target: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Reactivity: Mouse, Rat

Host: Goat

Clonality: Polyclonal

Conjugate: This OGG1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-OGG1 Antibody

Binding Specificity: Internal Region

Specificity: This antibody reacts to OGG1.

Cross-Reactivity (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Rat.

Purification: Affinity chromatography

Immunogen: Peptide with sequence C-HPKTSQAKGPSPLANK, from the internal region of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/128000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for OGG1

Target: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Alternative Name: OGG1

Background: The Ogg1 gene encodes a DNA repair enzyme (N glycosylase/DNA lyase) that incises DNA at 8 oxoG residues. N glycosylase/DNA lyase excises 7,8 dihydro 8 oxoguanine and 2,6 diamino 4 hydroxy 5 N methylformamidopyrimidine (FAPY) from damaged DNA. N glycosylase/DNA lyase has a beta lyase activity that nicks DNA 3' to the lesion. Alternative splicing of the C terminal region of the Ogg1 gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N terminal region in common. Many alternative splice variants for this gene have been described, but the full length nature for every variant has not been determined. The N terminus of this gene contains a mitochondrial targetting signal, essential for mitochondrial localization.Synonyms: MMH, MUTM, N-glycosylase/DNA lyase, OGH1

Gene ID: 4968, 9606

UniProt: O15527

Pathways: DNA Damage Repair