APOC1 antibody (C-Term)

Catalog No. ABIN375143

The Goat Polyclonal anti-APOC1 antibody is suitable to detect APOC1 in samples from Human. It has been validated for IHC (p).

Quick Overview for APOC1 antibody (C-Term) (ABIN375143)

Target: APOC1 (Apolipoprotein C-I (APOC1))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This APOC1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-APOC1 Antibody

Binding Specificity: C-Term

Specificity: This antibody recognizes Apolipoprotein CI (Apo CI).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence C-ETFQKVKEKLKIDS, from the C-Terminus of the protein sequence according to NP_001636.1.

Application Details

Application Notes: Peptide ELISA: Detection Limit Dilution: 1/8000. Immunohistochemistry on Paraffin Sections: 3-5 μg/mL. In paraffin embedded Human Liver shows spotty staining in the cytoplasm of hepatocytes.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for APOC1

Target: APOC1 (Apolipoprotein C-I (APOC1))

Alternative Name: Apolipoprotein C I (Apo CI)

Background: Apolipoprotein CI is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Apolipoprotein C-I appears to modulate the interaction of APOE with beta migrating VLDL and inhibit binding of beta VLDL to the LDL receptor related protein. At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individuals' relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL).Synonyms: Apo-CI, Ap °C-I, Ap °C1, Apolipoprotein C-I, Apolipoprotein C1

Gene ID: 341, 9606

UniProt: P02654

Pathways: Apoptosis