CPT1C antibody (Internal Region)

Catalog No. ABIN375150

The Goat Polyclonal anti-CPT1C antibody (ABIN375150) specifically detects CPT1C in WB. The antibody is reactive with Human, Dog and Cow samples.

Quick Overview for CPT1C antibody (Internal Region) (ABIN375150)

Target: CPT1C (Carnitine Palmitoyltransferase 1C (Brain) (CPT1C))

Reactivity: Human, Dog, Cow

Host: Goat

Clonality: Polyclonal

Conjugate: This CPT1C antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CPT1C Antibody

Binding Specificity: Internal Region

Specificity: This antibody reacts to CPT1C.

Cross-Reactivity (Details): Species reactivity (expected):Canine, Bovine.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogen: Peptide with sequence C-KSSTKTDSHRLGQH, from the internal region of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/16000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CPT1C

Target: CPT1C (Carnitine Palmitoyltransferase 1C (Brain) (CPT1C))

Alternative Name: CPT1C / CPT1-B

Background: The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine.Synonyms: CPT IC, Carnitine O-palmitoyltransferase 1, Carnitine palmitoyltransferase 1C, brain isoform

Gene ID: 126129, 9606

UniProt: Q8TCG5

Pathways: AMPK Signaling, Monocarboxylic Acid Catabolic Process