CPT1C antibody (C-Term)

Catalog No. ABIN655406

The Rabbit Polyclonal anti-CPT1C antibody is suitable to detect CPT1C in samples from Human. It has been validated for WB and FACS.

Quick Overview for CPT1C antibody (C-Term) (ABIN655406)

Target: CPT1C (Carnitine Palmitoyltransferase 1C (Brain) (CPT1C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPT1C antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB19024

Product Details anti-CPT1C Antibody

Binding Specificity: AA 752-782, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CPT1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 752-782 amino acids from the C-terminal region of human CPT1C.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for CPT1C

Target: CPT1C (Carnitine Palmitoyltransferase 1C (Brain) (CPT1C))

Alternative Name: CPT1C

Background: The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine.

Molecular Weight: 90989

Gene ID: 126129

NCBI Accession: NP_001129524, NP_001186681, NP_001186682, NP_689572

UniProt: Q8TCG5

Pathways: AMPK Signaling, Monocarboxylic Acid Catabolic Process