H2-D1 antibody

Catalog No. ABIN375490

This Mouse Monoclonal antibody specifically detects H2-D1 in FACS, IP, CMCD, BR and IHC (fro). It exhibits reactivity toward Mouse.

Quick Overview for H2-D1 antibody (ABIN375490)

Target: H2-D1 (Histocompatibility 2, D Region Locus 1 (H2-D1))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This H2-D1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Complement Mediated Cell Depletion (CMCD), Blocking Reagent (BR), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 28-14-8

Product Details anti-H2-D1 Antibody

Purpose: Mouse Anti-Mouse H-2Db-LE/AF

Specificity: Mouse H-2Db

Characteristics: Low Endotoxin/Azide Free Anti-Mouse H-2Db antibody for use in flow cytometry, immunohistochemistry, immunoprecipitation, CMCD, and blocking assays.

Endotoxin Level: Low Endotoxin

Immunogen: C3H.SW mouse splenocytes

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Preservative: Azide free

Handling Advice: Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: 4 °C

Storage Comment: 2-8°C

Target Details for H2-D1

Target: H2-D1 (Histocompatibility 2, D Region Locus 1 (H2-D1))

Alternative Name: H-2Db

Background: The 'classical' MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic α chains noncovalently associated with the invariant β 2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8 + T lymphocytes, which are usually cytotoxic T cells. MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8 + T cells during T cell ontogeny.

Gene ID: 14964

UniProt: P01899

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process