|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Vascular Endothelial Growth Factor C (VEGFC) antibody
|Synonyms||VRP, Flt4-L, VEGF-C, AW228853, VEGFC, MGC136707, vegf-c, xvegf-c, MGC85010|
Alternatives Western Blotting (WB), ELISA
|5 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This monoclonal antibody is generated from mice immunized with three KLH conjugated synthetic peptides selected from the N-terminal, central, and C-terminal regions of human VEGF3.|
|Description||Other names: Vascular Endothelial Growth Factor C, VEGF-C, Vascular endothelial growth factor-related protein, VRP, Flt4 ligand, Flt4-L, VEGF3|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||This monoclonal antibody is generated from mice immunized with three KLH conjugated synthetic peptides selected from the N-terminal, central, and C-terminal regions of human VEGF3.|
|Molecular Weight||46883 DA|
Background: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
|Application Notes||ELISA~~1:1,000 Western blotting~~1:100~500|
|Buffer||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cell Signaling, Cell Structure, Cancer, Cell Cycle|
|Restrictions||For Research Use only|
|Western analysis of extracts from HDMEC cells using VEGF3 antibody.|
Romero, Velez Edwards, Kusanovic et al.: "Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes." in: American journal of obstetrics and gynecology, Vol. 202, Issue 5, pp. 431.e1-34, 2010 (PubMed).
Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).
Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).
Deguchi, Ichikawa, Soga et al.: "Clinical significance of vascular endothelial growth factors C and D and chemokine receptor CCR7 in gastric cancer." in: Anticancer research, Vol. 30, Issue 6, pp. 2361-6, 2010 (PubMed).
Romero, Friel, Velez Edwards et al.: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).
|Hosts||Rabbit (52), Mouse (7), Goat (3)|
|Reactivities||Human (49), Mouse (Murine) (29), Rat (Rattus) (27)|
|Applications||Western Blotting (WB) (43), ELISA (33), Immunohistochemistry (IHC) (21), Immunofluorescence (IF) (16), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7), Immunoprecipitation (IP) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Flow Cytometry (FACS) (1), Immunocytochemistry (ICC) (1), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)|
|Conjugates||Biotin (5), FITC (4), HRP (3), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||Internal Region (2), N-Term (2), AA 104-330 (1), C-Term (1), Isoform 103 (1), pThr189 (1)|