|+1 404 474 4654|
|+1 888 205 9894 (TF)|
HtrA Serine Peptidase 1 (HTRA1) (C-Term) antibody
|Synonyms||PRSS11, L56, HtrA, ARMD7, ORF480, HTRA, Prss11, RSPP11, AI429470, MGC93339, htra1, zgc:92029, Xhtra1, zgc:172061, l56, htra, prss11, MGC145723|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|5 references available|
|Quantity||400 µL (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This HtrA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389~419 amino acids from the C-terminal region of human HtrA1.|
|Description||Other names: Serine protease HTRA1, L56|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This HtrA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389~419 amino acids from the C-terminal region of human HtrA1.|
|Molecular Weight||51286 DA|
Background: HtrA1 is a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Apoptosis/Necrosis, Cancer, Cell Structure|
|Restrictions||For Research Use only|
Chamberland, Wang, Jones et al.: "Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo." in: The Journal of biological chemistry, Vol. 284, Issue 40, pp. 27352-9, 2009 (PubMed).
Zumbrunn, Trueb: "Localization of the gene for a serine protease with IGF-binding domain (PRSS11) to human chromosome 10q25.3-q26.2." in: Genomics, Vol. 45, Issue 2, pp. 461-2, 1998 (PubMed).
Hu, Carozza, Klein et al.: "Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage." in: The Journal of biological chemistry, Vol. 273, Issue 51, pp. 34406-12, 1999 (PubMed).
Chien, Staub, Hu et al.: "A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer." in: Oncogene, Vol. 23, Issue 8, pp. 1636-44, 2004 (PubMed).
Howes, Lerch, Greenhalf et al.: "Clinical and genetic characteristics of hereditary pancreatitis in Europe." in: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, Vol. 2, Issue 3, pp. 252-61, 2004 (PubMed).
|Reactivities||Human (16), Mouse (Murine) (6), Rat (Rattus) (5), Cow (Bovine) (3), Dog (Canine) (3), Cat (Feline) (1), Chicken (1), Chimpanzee (1), Monkey (1)|
|Applications||Western Blotting (WB) (16), ELISA (12), Immunohistochemistry (IHC) (5), Immunofluorescence (IF) (2), Immunocytochemistry (ICC) (1), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (1), Immunoprecipitation (IP) (1)|
|Epitopes||N-Term (4), AA 234-249 (1), C-Term (1)|