Ataxin 1 antibody (AA 754-781)

Catalog No. ABIN389309

The Rabbit Polyclonal anti-Ataxin 1 antibody is suitable to detect Ataxin 1 in samples from Human. It has been validated for WB and IF.

Quick Overview for Ataxin 1 antibody (AA 754-781) (ABIN389309)

Target: Ataxin 1 (ATXN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ataxin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: RB16258

Product Details anti-Ataxin 1 Antibody

Binding Specificity: AA 754-781

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ATXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 754-781 amino acids from human ATXN1.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for Ataxin 1

Target: Ataxin 1 (ATXN1)

Alternative Name: ATXN1

Background: The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known.

Molecular Weight: 86923

Gene ID: 6310

NCBI Accession: NP_000323, NP_001121636

UniProt: P54253

Pathways: Synaptic Membrane