|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide) (ITGA5) (C-Term) antibody
|Synonyms||CD11C, SLEB6, Cr4, N418, Cd11c, AI449405, ITGAX, ITGA5, CD11c|
Alternatives Western Blotting (WB), Flow Cytometry (FACS), ELISA
|3 references available|
|Quantity||400 µL (0.25 mg/ml) (Variants)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This CD49e antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 803~832 amino acids from the C-terminal region of human CD49e.|
|Description||Other names: Integrin alpha-5, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49 antigen-like family member E, CD_antigen=CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, ITGA5|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This CD49e antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 803~832 amino acids from the C-terminal region of human CD49e.|
|Molecular Weight||114536 DA|
Background: CD49e belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein is the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100 Flow cytometric~~1:10~50|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Stem Cells|
|Restrictions||For Research Use only|
Schornberg, Shoemaker, Dube et al.: "Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 19, pp. 8003-8, 2009 (PubMed).
Okazaki, Ni, Ayeni et al.: "alpha5beta1 Integrin blockade inhibits lymphangiogenesis in airway inflammation." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2378-87, 2009 (PubMed).
Boehmler, Drost, Jaggy et al.: "The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 11, pp. 6789-98, 2009 (PubMed).