C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (Tyr251) antibody

Details for Product No. ABIN389507
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Antigen
Synonyms ABL1, ABL, CABL, ABLL, cb272, JTK7, bcr/abl, c-ABL, p150, v-abl, AI325092, Abl, E430008G22Rik, c-Abl, MTP
Epitope
Tyr251
(49), (35), (31), (26), (25), (17), (16), (14), (13), (13), (13), (12), (12), (12), (12), (12), (12), (12), (12), (11), (9), (7), (7), (6), (5), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(507), (342), (289), (204), (193), (180), (60), (48), (4), (1), (1)
Host
Rabbit
(501), (20)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(26), (23), (23), (19), (19), (19), (19), (19), (19), (19), (19), (8), (8), (8)
Application
Western Blotting (WB)
(291), (190), (153), (115), (114), (49), (23), (20), (15), (10), (2)
Pubmed 4 references available
Quantity 400 µL
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Catalog No. ABIN389507
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Immunogen This ABL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y251 of human ABL.
Clone RB7354
Isotype Ig
Specificity This ABL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y251 of human ABL.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ABL
Background ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length. The peptide used to generate this antibody is 100% conserved between ABL2 and ABL1.
Synonyms: Tyrosine-protein kinase ABL2, Abelson murine leukemia viral oncogene homolog 2, Tyrosine kinase ARG, ABL2, ABLL, ARG,
Molecular Weight 128343 DA
Gene ID 27
UniProt P42684
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Cycle, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.26 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (Tyr251) antibody Western blot analysis of anti-ABL Antibody (Y251) (ABIN389507) in A2058 cell line lysates (35 µg/lane). ABL(arrow) was detected using the purified polyclonal antibody.
Background publications Kruh, Perego, Miki et al.: "The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 15, pp. 5802-6, 1990 (PubMed).

Kruh, King, Kraus et al.: "A novel human gene closely related to the abl proto-oncogene." in: Science (New York, N.Y.), Vol. 234, Issue 4783, pp. 1545-8, 1987 (PubMed).

Cao, Leng, Kufe: "Catalase activity is regulated by c-Abl and Arg in the oxidative stress response." in: The Journal of biological chemistry, Vol. 278, Issue 32, pp. 29667-75, 2003 (PubMed).

Cao, Leng, Liu et al.: "Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases." in: Biochemistry, Vol. 42, Issue 35, pp. 10348-53, 2003 (PubMed).

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