Cyclin-Dependent Kinase 1 (CDK1) (pSer39) antibody

Details for Product No. ABIN389538
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Antigen
Synonyms
5363, CDC2, CDCDm, CDK1, CDK1/CDC2, CG5363, Cdc2, Cdk-1, Cdk1, Dcdc2, Dm cdc2, DmCdc2, DmCdk1, Dmcdc2, Dmel\\CG5363, cdc, cdc2Dm, cdk1, dCdk1, group 4, l(2)31Eh, CDC28A, P34CDC2, Cdc2a, p34, cdc ... show more
5363, CDC2, CDCDm, CDK1, CDK1/CDC2, CG5363, Cdc2, Cdk-1, Cdk1, Dcdc2, Dm cdc2, DmCdc2, DmCdk1, Dmcdc2, Dmel\\CG5363, cdc, cdc2Dm, cdk1, dCdk1, group 4, l(2)31Eh, CDC28A, P34CDC2, Cdc2a, p34, cdc2, wu:fc30e01, zgc:92032, PSTAIR, cdc-2, cdc2-a, cdc28a, cdc2x1.1, p34cdc2, xcdc2, CDC2A, CDC2AAT, CDK2, CDKA1, CDKA;1, CYCLIN-DEPENDENT KINASE A;1, cell division control 2, POL3, pold show less
Epitope
pSer39
(64), (52), (52), (28), (19), (18), (16), (13), (12), (9), (7), (7), (6), (6), (6), (6), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(477), (248), (235), (45), (37), (30), (27), (26), (16), (7), (6), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(394), (123)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(21), (15), (15), (9), (9), (9), (6), (6), (6), (6), (6), (6), (6), (6), (1), (1)
Application
Dot Blot (DB), Western Blotting (WB), Immunohistochemistry (IHC)
(429), (198), (115), (109), (64), (63), (60), (45), (27), (21), (10), (8), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN389538
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Immunogen This CDK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S39 of human CDK1.
Clone RB7849
Isotype Ig
Specificity This Phospho-CDK1-S39 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S39 of human CDK1.
Predicted Reactivity Cow (Bovine),Chicken,Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CDK1
Background The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.
Synonyms: V-abl Abelson murine leukemia viral oncogene homolog 1, ABL1,
Molecular Weight 34095 DA
Gene ID 983
UniProt P06493
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Application Notes DB = 1:500, WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.41 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Cyclin-Dependent Kinase 1 (CDK1) (pSer39) antibody Dot blot analysis of anti-CDK11-S39 Phospho-specific Pab (ABIN389538) on nitrocellulose membrane. 50 ng of nonphospho-peptide or phospho-peptide were adsorbed on their respective dots. Antibody working concentration was 0.5 µg/mL.
anti-Cyclin-Dependent Kinase 1 (CDK1) (pSer39) antibody (2) The anti-Phospho-CDK1-S39 Pab (ABIN389538) is used in Western blot for detection in Ramos tissue lysate.
anti-Cyclin-Dependent Kinase 1 (CDK1) (pSer39) antibody (3) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Chow, Siu, Ho et al.: "Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 40815-28, 2003 (PubMed).

Shapira, Ben-Izhak, Bishara et al.: "Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma." in: Cancer, Vol. 100, Issue 8, pp. 1615-21, 2004 (PubMed).

Krämer, Mailand, Lukas et al.: "Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase." in: Nature cell biology, Vol. 6, Issue 9, pp. 884-91, 2004 (PubMed).

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